Azelastine EP Impurity E (Z-Isomer) CAS 105279-16-1
| CAS No. | 105279-16-1 |
| Molecular Formula | C15H9ClO2 |
| Molecular Weight | 256.68 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, a polycyclic aromatic system, Azelastine EP Impurity E (Z-Isomer) is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 256.68 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Azelastine EP Impurity E (Z-Isomer) (CAS 105279-16-1) is a certified pharmaceutical impurity reference standard with the molecular formula C15H9ClO2 and a molecular weight of 256.68 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H9ClO2 |
| Molecular Weight | 256.68 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
Related Azelastine Standards
- Azelastine EP Impurity E (CAS 20526-97-0)
- Azelastine impurity 61 (CAS CATO-C4X-139661)
- Azelastine impurity 53 (CAS CATO-C4X-139653)
- Azelastine EP Impurity B (CAS 110406-94-5)
- Azelastine Impurity 46 (CAS 109386-70-1)
- Azelastine EP Impurity D (CAS 53242-88-9)
- Azelastine Impurity 67 (CAS CATO-C4X-139667)
- Azelastine Impurity 68 (CAS CATO-C4X-139668)
Recommended Standards
- Methyl (E)-2-(4-chloro-2-methylphenoxy)-3-methoxyacrylate (CAS 255908-42-0)
- Ethyl 4-(4-chlorophenoxy)-3-oxobutanoate (CAS 97900-77-1)
- Ethyl 3-(2-chloro-4-methoxyphenyl)-3-oxopropanoate (CAS 941696-11-3)
- Cinepazide Impurity 12 (CAS 10263-19-1)
- Apixaban Impurity 165 (CAS CATO-C4X-1088165)
- Sertraline Impurity 65 (Mixture of Enantiomers) (CAS 2124277-88-7)
- Methotrexate EP Impurity H HBr (CAS 67022-39-3(free base))
- N-[3-(1H-imidazol-1-yl)propyl]-4-methyl-1,3-benzothiazol-2-amine (CAS 1177334-28-9)
- 2,6-Bis[[2-[(4R)-4,5-dihydro-4-phenyl-2-oxazolyl]phenoxy]methyl]pyridine (CAS 850533-56-1)
- 5-Iodo-2-methoxyphenyl 4-methyl benzenesulfonate (CAS 910629-23-1)
- 7-Bromo-1,5-naphthyridin-4(1H)-one (CAS 1151802-14-0)
- 2-Methyl-5-nitroquinoline-8-thiol (CAS 1023816-04-7)
- Ethyl 3-bromo-5-ethoxy-4-((2-fluorobenzyl)oxy)benzoate (CAS 1706446-95-8)
- Semaglutide Impurity 187 (CAS CATO-C4X-2226187)
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