Tadalafil Impurity 31 CAS 2058231-08-4
| CAS No. | 2058231-08-4 |
| Molecular Formula | C21H17ClN2O5 |
| Molecular Weight | 412.82 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Tadalafil Impurity 31 (CAS 2058231-08-4, C21H17ClN2O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Tadalafil Impurity 31 (C21H17ClN2O5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H17ClN2O5 |
| Molecular Weight | 412.82 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Tadalafil Standards
- Tadalafil Impurity 145 (CAS 629652-47-7)
- Tadalafil Impurity 139 (CAS CATO-C4X-1087139)
- Tadalafil Impurity 57 (CAS CATO-C4X-108757)
- Tadalafil impurity 126 (CAS CATO-C4X-1087126)
- Tadalafil Impurity 171 (CAS CATO-C4X-1087171)
- Tadalafil Impurity 162 (CAS CATO-C4X-1087162)
- Tadalafil Impurity 82 (CAS CATO-C4X-108782)
- Tadalafil Impurity 106 (CAS 1356345-67-9)
Recommended Standards
- 2-{[5-(6-chloro-3-pyridyl)-4-methyl-4H-1,2,4-triazol-3-yl]thio}-1-[3-(trifluoromethyl)phenyl]ethan-1-one (CAS 680217-47-4)
- (6aR,10aS)-10a-(4-chlorophenylsulfonyl)-1,4-difluoro-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-8(9H)-one (CAS 944945-07-7)
- Imazosulfuron (CAS 122548-33-8)
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- Upadacitinib Impurity 9 (CAS CATO-C4X-24059)
- Fasudil Impurity 23 DiHCl (CAS 116700-36-8)
- Captopril Impurity 40 (CAS 122130-63-6)
- 2-Methoxy-5-methyl-6H-1,3-thiazine (CAS 89996-48-5)
- 2-Palmitoyl-sn-glycero-3-phosphocholine (CAS 66757-27-5)
- Ethyl 3,6-dibromo-2-fluorophenylacetate (CAS 1806351-20-1)
- 4-Methoxy-2,2-dimethylbutan-1-amine (CAS 1266895-35-5)
- 2-((3-Nitroacridin-9-yl)thio)acetic acid (CAS 124330-40-1)
- N1-Cyclopropyl-N1-methylbenzene-1,4-diamine (CAS 1095038-67-7)
- Peptide YY (human) trifluoroacetate salt (CAS 118997-30-1)
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