Sitagliptin Impurity 148 CAS 2072867-07-1
| CAS No. | 2072867-07-1 |
| Molecular Formula | C26H23F9N6O2 |
| Molecular Weight | 622.49 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Sitagliptin Impurity 148 is typically pale yellow to yellow amorphous powder. Its solid-state physicochemical attributes — including a molecular weight of 622.49 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Sitagliptin Impurity 148 (CAS 2072867-07-1) is a certified pharmaceutical impurity reference standard with the molecular formula C26H23F9N6O2 and a molecular weight of 622.49 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C26H23F9N6O2 |
| Molecular Weight | 622.49 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 6 |
Related Sitagliptin Standards
- Sitagliptin Impurity 55 (CAS CATO-C4X-114455)
- Sitagliptin Carbamoyl Glucuronide (CAS 940002-59-5)
- Sitagliptin Impurity 106 (CAS CATO-C4X-1144106)
- Sitagliptin Impurity 103 (CAS CATO-C4X-1144103)
- Sitagliptin impurity 113 (CAS CATO-C4X-1144113)
- Sitagliptin Impurity N53 (CAS 2379621-81-3)
- Sitagliptin Impurity 2 (CAS 769195-20-2)
- Sitagliptin Tablets EP Impurity FP-A (CAS 2088771-60-0)
Recommended Standards
- Clerodendrin (CAS 119738-57-7)
- 5,5-Dinitro-BAPTA-tetramethyl Ester (CAS 125367-35-3)
- 1-(Tert-butyl) 2-methyl 7-(benzyloxy)-5-((tert-butoxycarbonyl)amino)-4-iodo-1H-indole-1,2-dicarboxylate (CAS 919535-06-1)
- 2,2',2'',2'''-(((3',6'-Dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-4',5'-diyl)bis(methylene))bis(azanetriyl))tetraacetic acid (CAS 207124-64-9)
- Prednisolone Impurity 21 (CAS CATO-C4X-173721)
- Brivudine Impurity 13 (CAS 888-04-0)
- Tetrabenazine Impurity 35 (CAS CATO-C4X-274835)
- 2-(Diphenylphosphino)-1-phenylethanamine (CAS 2242399-86-4)
- Ethyl 2,2-Difluoro-2-(4-fluoro-3-methylphenyl)acetate (CAS 1227160-98-6)
- 2-Hydrazinyl-2-oxo-N-(o-tolyl)acetamide (CAS 53117-20-7)
- N-Hentriacontane (CAS 630-04-6)
- NGA3 N-Glycan (CAS 110387-63-8)
- (2-Bromophenyl)(morpholino)methanone (CAS 209962-07-2)
- Tau Peptide (401-411)-Lys-Lys trifluoroacetate salt (CAS 2022956-59-6)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com