Sitagliptin Tablets EP Impurity FP-A CAS 2088771-60-0
| CAS No. | 2088771-60-0 |
| Molecular Formula | C20H19F6N5O5 |
| Molecular Weight | 523.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Sitagliptin Tablets EP Impurity FP-A (CAS 2088771-60-0) is a certified pharmaceutical impurity reference standard with the molecular formula C20H19F6N5O5 and a molecular weight of 523.39 g/mol.
Structurally, Sitagliptin Tablets EP Impurity FP-A (C20H19F6N5O5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 11.0, corresponding to approximately 11 ring(s) or double-bond equivalent(s). With a molecular weight of 523.39 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C20H19F6N5O5 |
| Molecular Weight | 523.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
Related Sitagliptin Standards
- Sitagliptin Impurity 165 (CAS CATO-C4X-1144165)
- Sitagliptin Impurity 97 (CAS 1169707-29-2)
- Sitagliptin Impurity 22 (CAS 486460-23-5)
- Sitagliptin Impurity 2 (CAS 769195-20-2)
- Sitagliptin Impurity 149 (CAS CATO-C4X-1144149)
- Sitagliptin Impurity 87 (CAS CATO-C4X-114487)
- Sitagliptin Impurity N53 (CAS 2379621-81-3)
- Sitagliptin impurity 113 (CAS CATO-C4X-1144113)
Recommended Standards
- (E)-[1-(4-{4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}phenyl)ethylidene][(4-chlorophenyl)methoxy]amine (CAS 337919-67-2)
- Halometasone Impurity 1 (CAS 23961-24-2)
- JNJ DGAT2-A (CAS 1962931-71-0)
- Methyl 4-(2-((5-(2-bromophenyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetamido)benzoate (CAS 332934-88-0)
- Tirofiban Impurity 95 (CAS CATO-C4X-125495)
- Imrecoxib Impurity 8 (CAS CATO-C4X-23798)
- Haloperidol Impurity 37 (CAS 84819-46-5)
- N-(4-Bromophenyl)ethanesulfonamide (CAS 57616-20-3)
- 1-Methanesulfonyl-2-methyl-2,3-dihydro-1h-indole-5-carboxylic acid (CAS 851116-22-8)
- 4-[(2-Methylpropan-2-yl)oxycarbonyl]-5,6-dihydrothieno[3,2-b]pyrrole-2-carboxylic acid (CAS 1250999-99-5)
- 2-Propenoic acid, 2-methyl-, polymer with ethenylbenzene, 2-ethylhexyl 2-propenoate and methyl 2-methyl-2-propenoate (CAS 28377-44-8)
- 4-Methyl-3,4-dihydroquinazolin-2(1H)-one (CAS 31402-74-1)
- 5-(1-Benzylpiperidin-2-yl)-2-chloro-4-methylpyridine (CAS 1352531-23-7)
- Polyphemusin II-Derived Peptide (CAS 229030-20-0)
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