2-Chloro-4-fluoro-5-methylbenzoic acid CAS 208165-96-2

Purity 97%+In StockPharmaceutical Standards
CAS No.208165-96-2
Molecular FormulaC8H6ClFO2
Molecular Weight188.58 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

2-Chloro-4-fluoro-5-methylbenzoic acid CAS 208165-96-2 chemical structure

Description

Compared with other compounds in its class, the molecular weight of 188.58 g/mol gives 2-Chloro-4-fluoro-5-methylbenzoic acid distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

2-Chloro-4-fluoro-5-methylbenzoic acid (CAS 208165-96-2), molecular formula C8H6ClFO2 and molecular weight 188.58 g/mol, is a CATO reference standard with documented purity and traceability.

2-Chloro-4-fluoro-5-methylbenzoic acid (C8H6ClFO2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), 2-Chloro-4-fluoro-5-methylbenzoic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC8H6ClFO2
Molecular Weight188.58 g/mol
AppearanceOff-white to pale yellow crystalline powder. (slight halide-like odor, low volatility)
Purity97%+
StorageStore at 2-8°C, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in methanol, acetonitrile, DMSO, water (slightly soluble)
StabilityMay oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)5.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)2016
Halogen ContentF/Cl-containing

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