Topiramate EP Impurity A CAS 20880-92-6
| CAS No. | 20880-92-6 |
| Molecular Formula | C12H20O6 |
| Molecular Weight | 260.28 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Topiramate EP Impurity A (CAS 20880-92-6, C12H20O6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C12H20O6, Topiramate EP Impurity A contains a carboxylic acid group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 260.28 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H20O6 |
| Molecular Weight | 260.28 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1962 |
Related Topiramate Standards
- Topiramate Impurity 24 (CAS 582-52-5)
- Topiramate Impurity 25 (CAS 25018-67-1)
- Topiramate Impurity 40 (CAS CATO-C4X-176840)
- Topiramate Impurity 15 (CAS 128316-82-5)
- Topiramate Didesacetal Impurity (CAS 106881-42-9)
- Topiramate Impurity 12 (CAS CATO-C4X-176812)
- Topiramate Impurity 1 (CAS 32785-90-3)
- Topiramate Impurity 13 (CAS 86569-78-0)
Recommended Standards
- Penfluridol Impurity 7 (CAS 1489363-63-4)
- Monobenzyl Phthalate-d4 (CAS 478954-83-5)
- Methyl 1-((2,4-dimethylphenoxy)methyl)-1h-pyrazole-3-carboxylate (CAS 1001500-23-7)
- Rosuvastatin Impurity 71 (CAS CATO-C4X-116971)
- Cabozantinib Impurity 27 (CAS 332-07-0)
- Lincomycin EP Impurity C (CAS 14600-41-0)
- Pretomanid Impurity 31 (CAS CATO-C4X-260631)
- Phenylmethyl (3alpha,5beta,7alpha)-6-Ethylidene-3,7-dihydroxy-cholan-24-oic Acid Ester (CAS 1352328-67-6)
- 3-((3-Chlorobenzyl)oxy)propane-1-sulfonyl chloride (CAS 1463435-85-9)
- methyl 3-amino-6-methylpyrazine-2-carboxylate (CAS 2032-84-0)
- 3-(3-Chlorophenoxymethyl)benzoic acid (CAS 360778-44-5)
- (2-Methylazetidin-2-yl)methanol (CAS 1314951-93-3)
- N-Iodosaccharin (CAS 86340-94-5)
- Neuropeptide GE (CAS 134748-04-2)
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