Topiramate Impurity 1 CAS 32785-90-3
| CAS No. | 32785-90-3 |
| Molecular Formula | C12H19ClO5 |
| Molecular Weight | 278.73 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Topiramate Impurity 1 is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Topiramate Impurity 1 (CAS 32785-90-3), a pharmacopoeial impurity reference standard (molecular formula C12H19ClO5, MW 278.73 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, Topiramate Impurity 1 is typically white to off-white crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 278.73 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Topiramate Impurity 1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H19ClO5 |
| Molecular Weight | 278.73 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1966 |
| Halogen Content | Cl-containing |
Related Topiramate Standards
- Topiramate Impurity 12 (CAS CATO-C4X-176812)
- Topiramate Impurity 24 (CAS 582-52-5)
- Topiramate Impurity 25 (CAS 25018-67-1)
- Topiramate Impurity 40 (CAS CATO-C4X-176840)
- Topiramate EP Impurity A (CAS 20880-92-6)
- Topiramate Impurity 15 (CAS 128316-82-5)
- Topiramate Didesacetal Impurity (CAS 106881-42-9)
- Topiramate EP Impurity C (CAS 106881-41-8)
Recommended Standards
- Baclofen impurity 32 (CAS CATO-C4X-101232)
- 2-Chloro-N-(1-(3-cyanopyridin-2-yl)piperidin-4-yl)acetamide (CAS 1065484-49-2)
- Baclofen impurity 31 (CAS CATO-C4X-101231)
- 2-Chloro-7-cyclopentyl-N-methyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide (CAS 1211444-14-2)
- Iohexol impurity 42 (CAS CATO-C4X-166442)
- Tofacitinib Impurity 130 (CAS 2564-07-0)
- Mosapride Impurity 8 (CAS 112885-33-3)
- 1'-Benzyl-3,4-dihydro-2H-spiro[naphthalene-1,2'-pyrrolidin]-5'-one (CAS 159757-39-8)
- 4-(Difluoromethyl)-6-iodo-2-methoxypyridin-3-ol (CAS 1804373-78-1)
- Orforglipron impurity 27 (CAS 465529-57-1)
- (S)-3-(4-bromophenyl)pyrrolidine (CAS 1336356-34-3)
- Butyl Myristate (CAS 110-36-1)
- (3R)-1-(Pyrimidin-4-yl)pyrrolidin-3-amine dihydrochloride (CAS 1365936-54-4)
- Semaglutide Impurity 10 (CAS CATO-C4X-222610)
Why CATO?
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- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com