Palbociclib Impurity 126 CAS 2089333-12-8
| CAS No. | 2089333-12-8 |
| Molecular Formula | C9H11N5O3 |
| Molecular Weight | 237.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Palbociclib Impurity 126 is closely related to an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Palbociclib Impurity 126 (CAS 2089333-12-8) is a certified pharmaceutical impurity reference standard with the molecular formula C9H11N5O3 and a molecular weight of 237.22 g/mol.
Palbociclib Impurity 126 (C9H11N5O3) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H11N5O3 |
| Molecular Weight | 237.22 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Nitrogen Atoms | 5 |
Related Palbociclib Standards
- Palbociclib Impurity 46 (CAS 1244949-62-9)
- Palbociclib Impurity 182 (CAS CATO-C4X-1125182)
- Palbociclib Impurity 184 (CAS CATO-C4X-1125184)
- Palbociclib Impurity 197 (CAS 1314997-73-3)
- Palbociclib Impurity 169 (CAS CATO-C4X-1125169)
- Palbociclib Impurity 151 (CAS CATO-C4X-1125151)
- Palbociclib Impurity 173 (CAS CATO-C4X-1125173)
- Palbociclib Impurity 179 (CAS CATO-C4X-1125179)
Recommended Standards
- Imatinib Impurity 91 (CAS CATO-C4X-106891)
- Etofenamate EP Impurity C (CAS 101-23-5)
- Biopterin (CAS 22150-76-1)
- L-Sepiapterin (CAS 17094-01-8)
- Imatinib Impurity 25 (CAS CATO-C4X-106825)
- Acetaminophen Impurity 34 (CAS 146897-60-1)
- Istradefylline Impurity 26 (CAS CATO-C4X-106126)
- (2R,3S)-3-hydroxypyrrolidine-2-carbonitrile hydrochloride (CAS 2306255-02-5)
- 1,4-Bis((2,3-epoxypropoxy)methyl)cyclohexane (CAS 14228-73-0)
- 4-(Difluoromethyl)-2-hydroxynicotinic acid (CAS 1805037-89-1)
- 1-Ethyl-3-(2-hydroxypropanoyl)urea (CAS 1154989-70-4)
- 2-Fluoro-1-(3-fluorophenyl)-4-methylbenzene (CAS 1214391-72-6)
- 6-Bromo-4-fluoro-1-methyl-1H-indazole (CAS 1358574-94-3)
- Semaglutide Impurity 142 (CAS CATO-C4X-2226142)
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