2-(3-(Difluoromethoxy)-4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane CAS 2092444-39-6
| CAS No. | 2092444-39-6 |
| Molecular Formula | C14H19BF2O4 |
| Molecular Weight | 300.11 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-(3-(Difluoromethoxy)-4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 2092444-39-6), molecular formula C14H19BF2O4 and molecular weight 300.11 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system, 2-(3-(Difluoromethoxy)-4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 300.11 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H19BF2O4 |
| Molecular Weight | 300.11 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | F-containing |
Related Difluoromethoxy Standards
- 2-(4-(Difluoromethoxy)-3-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1310950-03-8)
- (3-(2-(Difluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)methyl carbamimidothioate (CAS 1779132-99-8)
- 1-[2-(difluoromethoxy)benzoyl]piperidine-3-carboxylic acid (CAS 1016688-45-1)
- 4'-(Difluoromethoxy)-4,2':6',4''-terpyridine (CAS 1214348-06-7)
- 4'-(Difluoromethoxy)-3,2':6',3''-terpyridine (CAS 1214383-64-8)
- 4'-(Difluoromethoxy)-4,3':5',4''-terpyridine (CAS 1214391-86-2)
- (2-(4-(Difluoromethoxy)-3-isopropoxyphenyl)oxazol-4-yl)methanol (CAS 1574285-36-1)
- 5-{[4-(difluoromethoxy)-3-methoxyphenyl]methylidene}-1,3-thiazolidine-2,4-dione (CAS 894259-20-2)
Recommended Standards
- 2-(2-Bromo-4-cyano-6-ethoxyphenoxy)acetic acid (CAS 932843-98-6)
- 2-(3-Bromo-2-hydroxypropoxy)isoindoline-1,3-dione, >98% (CAS 80042-02-0)
- 2-(2,4-Difluoro-6-(methoxymethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 2641028-73-9)
- 2-(6-Amino-8-bromo-9H-purin-9-yl)ethyl acetate (CAS 874903-79-4)
- rac-Parconazole Oxalate (CAS 68685-55-2)
- 4-(Methylamino)but-2-ynoic acid (CAS 1823915-94-1)
- N-(2,4-dichlorophenyl)piperidine-2-carboxamide hydrochloride (CAS 1078163-25-3)
- 5-(4-Tert-butylphenyl)-4-phenyl-4H-1,2,4-triazole-3-thiol (CAS 124998-67-0)
- 2-Phenoxy-N-((1-(p-tolyl)-1H-tetrazol-5-yl)methyl)acetamide (CAS 920460-44-2)
- 1-(2,4-Difluorophenyl)-4-phenyl-1H-pyrazol-5-amine (CAS 1202029-37-5)
- 2-Iodo-1H,1H,1H,2H,3H,3H-perfluorononane (CAS 38550-34-4)
- Resmetirom impurity 122 (CAS 2639977-02-7)
- N-(4-(Benzo[d]thiazol-2-yl)phenyl)-2-((1-phenyl-1H-tetrazol-5-yl)thio)acetamide (CAS 690645-00-2)
- Custom peptides (CAS CATO-CPTD788509)
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