Benzyl 5-fluorospiro[indoline-3,4'-piperidine]-1'-carboxylate CAS 209348-85-6
| CAS No. | 209348-85-6 |
| Molecular Formula | C20H21FN2O2 |
| Molecular Weight | 340.39 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Benzyl 5-fluorospiro[indoline-3,4'-piperidine]-1'-carboxylate.
Benzyl 5-fluorospiro[indoline-3,4'-piperidine]-1'-carboxylate (CAS 209348-85-6), molecular formula C20H21FN2O2 and molecular weight 340.39 g/mol, is a CATO reference standard with documented purity and traceability.
Based on its molecular formula C20H21FN2O2, Benzyl 5-fluorospiro[indoline-3,4'-piperidine]-1'-carboxylate contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 340.39 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Benzyl 5-fluorospiro[indoline-3,4'-piperidine]-1'-carboxylate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H21FN2O2 |
| Molecular Weight | 340.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2016 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Benzyl Standards
- Benzyl 7-fluorospiro[indoline-3,4'-piperidine]-1'-carboxylate (CAS 1243359-99-0)
- Ethyl 4-(5-fluorospiro[indoline-3,4'-piperidin]-1'-yl)piperidine-1-carboxylate (CAS 927402-26-4)
- 1'-Benzyl-5-fluorospiro[indoline-3,4'-piperidin]-2-one (CAS 1258638-31-1)
- (5-Fluorospiro[indoline-3,4'-piperidin]-1-yl)(furan-2-yl)methanone (CAS 1422057-70-2)
- 1'-Benzyl-5-fluorospiro[1,2-dihydroindole-3,4'-piperidine] (CAS 1341040-27-4)
- 2-((6-Fluorospiro[3.3]heptan-2-yl)methyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 2715119-86-9)
- 2-(6-Fluorospiro[3.3]heptan-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 2715119-85-8)
- 6-Fluorospiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one (CAS 92926-32-4)
Recommended Standards
- 5-(morpholin-4-ylsulfonyl)-2-pyrrolidin-1-ylbenzoic acid (CAS 790271-13-5)
- ESCitalopram N-Oxide (CAS 917482-45-2)
- 4-{2-[5-(4-fluorophenyl)-2-methylpyrazolo[1,5-a]pyrimidin-6-yl]ethyl}morpholine (CAS 861207-03-6)
- Ethyl 2-(3-oxo-1-tosylpiperazin-2-yl)acetate (CAS 318288-64-1)
- 1-Methyl-5-(3-(trifluoromethyl)phenyl)pyrimidine-4(1H)-thione (CAS 62953-72-4)
- Aceclidine Impurity 4 (CAS 603121-55-7)
- 1,1,1,2,2,3,3-Heptafluoro-3-[[1,1,1,2,3,3-hexafluoro-3-[[1,1,1,2,3,3-hexafluoro-3-(1,2,2,2-tetrafluoroethoxy)propan-2-yl]oxy]propan-2-yl]oxy]propane (CAS 3330-16-3)
- Tert-butyl 1-(4-amino-1,2,5-oxadiazol-3-yl)-5-methyl-1H-1,2,3-triazole-4-carboxylate (CAS 311321-42-3)
- 5,5-difluorospiro[6H-pyrano[3,4-b]pyridine-8,3'-tetrahydrofuran] (CAS 2761389-78-8)
- 3-Acetyl-6-chloropyridazine (CAS 214701-31-2)
- 3-(Benzylamino)-[1,2,4]triazolo[4,3-a]pyridine-6-carboxylic acid (CAS 1119452-12-8)
- Methyl 5-bromo-2-cyano-3-(difluoromethyl)benzoate (CAS 1805412-26-3)
- Nirmatrelvir Impurity 6 (CAS CATO-C4X-28746)
- Semaglutide Impurity 130 (CAS 1188328-40-6)
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