2,2,2-Trifluoro-N,N-bis(trimethylsilyl)acetamide CAS 21149-38-2
| CAS No. | 21149-38-2 |
| Molecular Formula | C8H18F3NOSi2 |
| Molecular Weight | 257.40 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
2,2,2-Trifluoro-N,N-bis(trimethylsilyl)acetamide (CAS 21149-38-2), molecular formula C8H18F3NOSi2 and molecular weight 257.40 g/mol, is a CATO reference standard with documented purity and traceability.
2,2,2-Trifluoro-N,N-bis(trimethylsilyl)acetamide (C8H18F3NOSi2) contains an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C8H18F3NOSi2 |
| Molecular Weight | 257.40 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | -1.0 |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Trifluoro Standards
- 2,2,2-Trifluoro-N,N-dimethyl-1-((triethylsilyl)oxy)ethan-1-amine (CAS 208331-60-6)
- 4-(2,2,2-Trifluoro-1-((trimethylsilyl)oxy)ethyl)morpholine (CAS 289706-46-3)
- 2,2,2-Trifluoro-N-(2-(prop-1-en-2-yl)phenethyl)acetamide (CAS 2632991-49-0)
- 2,2,2-Trifluoro-1-(5-methoxy-7-methyl-1H-indol-1-yl)ethan-1-one (CAS 1260832-07-2)
- 4,4,4-Trifluoro-3-(1h-indol-3-yl)butanoic acid (CAS 153233-36-4)
- 2,2,2-Trifluoro-N-(5-oxo-5,6,7,8-tetrahydronaphthalen-2-yl)acetamide (CAS 90401-87-9)
- 3,3,3-Trifluoro-2-(5-methyl-1h-indol-3-yl)propanoic acid (CAS 252729-38-7)
- 3,3,3-Trifluoro-2-(6-methyl-1h-indol-3-yl)propanoic acid (CAS 2197052-76-7)
Recommended Standards
- 2-(2-Hydroxyethyl)-7,7,9-trimethyl-1,2,4-triazaspiro[4.5]Decane-3-thione (CAS 352208-43-6)
- 3-(3-(Dimethylamino)propyl)-5-isobutyl-2-thioxoimidazolidin-4-one (CAS 86503-13-1)
- 1-[4-(cyclopentylamino)-2-(methylsulfanyl)pyrimidin-5-yl]ethan-1-one (CAS 362656-11-9)
- 3-(Methylthio)-4-oxo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carbothioamide (CAS 499771-14-1)
- 2-Amino-4-bromo-5-fluorobenzoic Acid (CAS 1374208-42-0)
- (1α,2β,3β,4α)-1,2,3,4-Tetrahydro-1,2,3,4-chrysenetetrol (CAS 127592-29-4)
- 3-(5-(1-Methyl-2-oxoindolin-3-ylidene)-4-oxo-2-thioxothiazolidin-3-yl)benzoic acid (CAS 306322-09-8)
- 2-amino-4-fluoro-5-hydroxybenzoic acid (CAS 1250931-52-2)
- 2-(9-(Tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)ethanethiol (CAS 920503-57-7)
- Triethanolamine Phosphate (CAS 10017-56-8)
- (S)-3-Oxocyclohexanecarboxylic acid (CAS 21531-46-4)
- 3-(6-fluoro-2-oxo-1,2,3,4-tetrahydroquinolin-1-yl)propanoic acid (CAS 1155516-10-1)
- 5-Bromo-6-isobutoxypyridin-3-amine (CAS 1517923-59-9)
- Semaglutide impurity 23 (CAS CATO-C4X-222623)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com