Glibenclamide EP Impurity B CAS 21165-77-5
| CAS No. | 21165-77-5 |
| Molecular Formula | C18H19ClN2O6S |
| Molecular Weight | 426.87 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Glibenclamide EP Impurity B is closely related to a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Glibenclamide EP Impurity B (CAS 21165-77-5) is a certified pharmaceutical impurity reference standard with the molecular formula C18H19ClN2O6S and a molecular weight of 426.87 g/mol.
Owing to a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution, Glibenclamide EP Impurity B is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 426.87 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Glibenclamide EP Impurity B under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C18H19ClN2O6S |
| Molecular Weight | 426.87 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Glibenclamide Standards
Recommended Standards
- 4-[4-(2-Chlorophenyl)-1,3-thiazol-2-yl]-N-(2,4-difluorophenyl)benzamide (CAS 338396-97-7)
- Lemborexant impurity 15 (CAS CATO-C4X-304215)
- 3-Chloro-N-[3-cyano-4-(4-methoxybenzenesulfonyl)phenyl]benzamide (CAS 477866-82-3)
- 1-Allyl-3-((4-chlorophenyl)sulfonyl)-2-imino-1H-dipyrido[1,2-a:2',3'-d]pyrimidin-5(2H)-one (CAS 606958-72-9)
- Posaconazole Impurity 172 (CAS CATO-C4X-1208172)
- Albendazole Impurity 28 (CAS CATO-C4X-153528)
- Fudosteine Impurity 80 (CAS CATO-C4X-144780)
- Clindamycin B palmitate HCl (CAS CATO-C4X-1341114)
- 2-(2-(Difluoromethyl)oxazol-4-yl)acetic acid (CAS 1783942-93-7)
- 3-(3-chloro-4-ethoxyphenyl)cyclohex-2-en-1-one (CAS 1503512-09-1)
- 1-(5-amino-2,4-difluoro-phenyl)hexahydropyrimidine-2,4-dione (CAS 2703773-11-7)
- 1,3,5-Tris(3,4-dichlorophenyl)-1,3,5-triazinane-2,4,6-trione (CAS 98329-02-3)
- 6-(Methylsulfonyl)-2-piperazin-1-yl-1,3-benzothiazole (CAS 1095538-90-1)
- Peptide Impurity 28 (CAS 1350456-64-2)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com