4,4-Difluoropiperidine-3-carbonitrile hydrochloride CAS 2116938-91-9
| CAS No. | 2116938-91-9 |
| Molecular Formula | C6H8F2N2 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4,4-Difluoropiperidine-3-carbonitrile hydrochloride.
4,4-Difluoropiperidine-3-carbonitrile hydrochloride (CAS 2116938-91-9) is a high-purity analytical reference standard with the molecular formula C6H8F2N2HCl and a molecular weight of 182.60 g/mol.
The molecular framework of 4,4-Difluoropiperidine-3-carbonitrile hydrochloride (C6H8F2N2HCl) is characterized by a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 4,4-Difluoropiperidine-3-carbonitrile hydrochloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H8F2N2 HCl |
| Molecular Weight | 182.60 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Difluoropiperidine Standards
- 1-Benzyl-4,4-difluoropiperidine-2,6-dione (CAS 1001337-74-1)
- 4,4-Difluoropiperidine-1-sulfonamide (CAS 1015170-98-5)
- 1-Benzyl-3,3-difluoropiperidine-4,4-diol (CAS 1067914-81-1)
- 4,4-Difluoropiperidine-1-sulfonyl chloride (CAS 1224929-81-0)
- Benzyl 4,4-difluoropiperidine-1-carboxylate (CAS 1226495-16-4)
- 3,5-Difluoropiperidine (CAS 1228631-14-8)
- 4,4-Difluoropiperidine-1-carbonyl chloride (CAS 1240057-29-7)
- Methyl 5,5-difluoropiperidine-2-carboxylate (CAS 1255663-85-4)
Recommended Standards
- 2-Chloro-N-(3-(thiomorpholinomethyl)phenyl)acetamide (CAS 1221820-88-7)
- 2-[1-(Dimethylamino)ethyl]indole (CAS 96286-10-1)
- Benzenecarbothioicacid,[(2-hydroxyphenyl)methylene]hydrazide,palladiumcomplex (CAS 132829-27-7)
- 4-{[(4-fluorophenyl)sulfanyl]methyl}-1-(phenylsulfonyl)-4-piperidinol 478041-56-4 KS-00001VVB (CAS 478041-56-4)
- n-(4-Chloro-2-fluorophenyl)methanesulfonamide (CAS 545384-21-2)
- Methyl 2-amino-3-bromo-4-methoxybenzoate (CAS 1180497-49-7)
- trimethyl(trichloromethyl)silane (CAS 5936-98-1)
- pyrrolo[2,1-f][1,2,4]triazine-7-carbaldehyde (CAS 1554288-05-9)
- 2,6-Bis((4S,5S)-4-isopropyl-5-phenyl-4,5-dihydrooxazol-2-yl)pyridine (CAS 1446271-21-1)
- C-Peptide 2 (rat) (CAS 41594-08-5)
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