Sumatriptan EP Impurity D CAS 212069-94-8
| CAS No. | 212069-94-8 |
| Molecular Formula | C14H21N3O3S |
| Molecular Weight | 311.40 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Sumatriptan EP Impurity D (C14H21N3O3S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Sumatriptan EP Impurity D (CAS 212069-94-8) is a certified pharmaceutical impurity reference standard with the molecular formula C14H21N3O3S and a molecular weight of 311.40 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H21N3O3S |
| Molecular Weight | 311.40 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2017 |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Sumatriptan Standards
- Sumatriptan impurity 1 (CAS CATO-C4X-17571)
- Sumatriptan impurity 2 (CAS CATO-C4X-17572)
- Sumatriptan-D6 (CAS 1020764-38-8)
- Sumatriptan impurity 3 (CAS CATO-C4X-17573)
- Sumatriptan EP Impurity C (CAS 1797905-62-4)
- Sumatriptan RC 2 (CAS 151140-66-8)
- Sumatriptan (CAS 103628-46-2)
- Sumatriptan impurity 5 (CAS 2250254-19-2)
Recommended Standards
- S-1H-Benzo[d]imidazol-2-yl 2-((2,3-dimethylphenyl)amino)ethanethioate (CAS 83408-79-1)
- tert-Butyl 2-(ethylthio)-4-hydroxy-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate (CAS 338740-07-1)
- N-Phenyl-5-(1-(p-tolyloxy)ethyl)-1,3,4-thiadiazol-2-amine (CAS 90299-95-9)
- tert-Butyl 2-(methylthio)-4-oxo-3,4,5,6,7,9-hexahydro-8H-pyrimido[4,5-c]azepine-8-carboxylate (CAS 2412424-99-6)
- Tolvaptan Impurity 103 (CAS CATO-C4X-1955103)
- Bisoprolol Impurity 70 (CAS 84425-10-5)
- Bortezomib Impurity 34 (CAS 862895-00-9)
- 2-Phenyl-4-(phenylsulfanyl)pyrimidine-5-carboxylic acid (CAS 477854-51-6)
- 5-((Benzyloxy)methyl)-3-bromoisoxazole (CAS 1220521-45-8)
- 2-(2-Tolyl)-4-(2-hydroxyphenyl)thiazole (CAS 1965305-06-9)
- 7-Methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carbaldehyde (CAS 623564-20-5)
- Pyridine-3-sulfinic acid (CAS 101084-77-9)
- 1-[(3-fluorophenyl)methyl]cyclopropane-1-carboxylic acid (CAS 1439902-29-0)
- Semaglutide-d5 (CAS CATO-C4X-2226153)
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