Bortezomib Impurity 34 CAS 862895-00-9
| CAS No. | 862895-00-9 |
| Molecular Formula | C19H22N4O2 |
| Molecular Weight | 338.40 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Bortezomib Impurity 34.
Bortezomib Impurity 34 (CAS 862895-00-9) is a certified pharmaceutical impurity reference standard with the molecular formula C19H22N4O2 and a molecular weight of 338.40 g/mol.
Based on its molecular formula C19H22N4O2, Bortezomib Impurity 34 contains a steroid core, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 338.40 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H22N4O2 |
| Molecular Weight | 338.40 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Nitrogen Atoms | 4 |
Related Bortezomib Standards
- Bortezomib Impurity 13 (CAS 1446194-56-4)
- Bortezomib Impurity 20 (CAS 862894-96-0)
- Bortezomib Impurity 64 (CAS 847644-46-6)
- Bortezomib Impurity 3 (CAS 289472-78-2)
- Bortezomib Impurity 4 (CAS 289472-81-7)
- Bortezomib Impurity 15 (CAS 275374-67-9)
- Bortezomib Impurity 78 (CAS 7364-51-4)
- Bortezomib Impurity 19 (CAS CATO-C4X-107219)
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