Sertraline Impurity 65 (Mixture of Enantiomers) CAS 2124277-88-7
| CAS No. | 2124277-88-7 |
| Molecular Formula | C17H17Cl2N |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Sertraline Impurity 65 (Mixture of Enantiomers) meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Sertraline Impurity 65 (Mixture of Enantiomers) (CAS 2124277-88-7, C17H17Cl2NHCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Sertraline Impurity 65 (Mixture of Enantiomers) (C17H17Cl2NHCl) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C17H17Cl2N HCl |
| Molecular Weight | 342.69 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Sertraline Standards
- Sertraline - Impurity C (Freebase) (CAS 107538-91-0)
- Sertraline Acetamide (CAS 1097616-52-8)
- Sertraline Carbamoyl Glucuronide (CAS 119733-44-7)
- Sertraline Impurity 26 (CAS 1198115-10-4（free base）)
- Sertraline RC 11 (CAS 1217630-23-3)
- Sertraline-d3 Hydrochloride (CAS 1217741-83-7)
- Sertraline Impurity 50 HCl (CAS 122873-20-5 (free base))
- Sertraline EP Impurity F Enantiomer (CAS 124379-29-9)
Recommended Standards
- Levobunolol impurity 2 (CAS CATO-C4X-29662)
- Sunitinib Impurity 38 (CAS CATO-C4X-133338)
- Drotaverine Impurity 16 (CAS 37491-68-2)
- 3-([1,1'-Biphenyl]-4-ylmethyl)piperazin-2-one (CAS 1260637-39-5)
- ONO-4057 (CAS 134578-96-4)
- Vildagliptin Impurity 97 (CAS CATO-C4X-110097)
- 1-(4-Chlorophenyl)-2-(tetrahydropyrimidin-2(1H)-ylidene)ethan-1-one (CAS 107165-83-3)
- (E)-2-((4-Methoxybenzylidene)amino)-1-phenylethan-1-ol (CAS 1283595-88-9)
- 2-(4-Amino-3-nitrophenoxy)ethan-1-ol (CAS 50982-74-6)
- Semaglutide impurity 56 (CAS CATO-C4X-222656)
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