Sertraline EP Impurity F Enantiomer CAS 124379-29-9
| CAS No. | 124379-29-9 |
| Molecular Formula | C16H12Cl2O |
| Molecular Weight | 291.17 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 291.17 g/mol gives Sertraline EP Impurity F Enantiomer distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Sertraline EP Impurity F Enantiomer (CAS 124379-29-9, C16H12Cl2O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a hydroxyl group, an ether linkage, chlorine substitution, a polycyclic aromatic system, Sertraline EP Impurity F Enantiomer is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 291.17 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H12Cl2O |
| Molecular Weight | 291.17 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | Cl-containing |
Related Sertraline Standards
- Sertraline Impurity N1 (CAS 152448-80-1)
- rac-Sertraline EP Impurity F (CAS 79560-19-3)
- Sertraline EP Impurity F (CAS 155748-61-1)
- Sertraline RC 6 (Base) (CAS 755752-66-0)
- Sertraline Impurity 1 (CAS 866018-46-4)
- Sertraline Impurity 66 (CAS CATO-C4X-134466)
- Sertraline Impurity 68 (CAS CATO-C4X-134468)
- Sertraline Impurity 72 (CAS CATO-C4X-134472)
Recommended Standards
- (E)-1-(3,5-dichlorophenyl)-3-(p-tolyl)prop-2-en-1-one (CAS 1217232-15-9)
- n-(4-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)cyclopropanamine (CAS 1256360-58-3)
- 2-((3,4-Dichlorophenyl)amino)-N-(1-methoxypropan-2-yl)acetamide (CAS 1209565-96-7)
- 4-(2,4-Dichlorophenyl)-3,4-dihydronaphthalen-1(2H)-one (CAS 127293-50-9)
- Ramosetron Impurity 17 (CAS 132036-42-1)
- Bisoprolol Impurity 81 (CAS 2775292-22-1)
- Trazodone Impurity 4 (CAS 1263278-79-0)
- 2-Propenoic acid, 2-methyl-, methyl ester, polymer with butyl 2-propenoate and chloroethene (CAS 25767-42-4)
- (1,2,3-Thiadiazol-4-yl)formamido 2,4-dichlorobenzoate (CAS 341965-66-0)
- 4-Methyl-N-(4-nitrophenyl)-N-(p-tolyl)aniline (CAS 20440-92-0)
- (Z)-3-(1H-Imidazol-2-yl)acrylic acid hydrochloride (CAS 1297344-68-3)
- 2-(1H-pyrrol-1-yl)acetonitrile (CAS 86241-05-6)
- 1-(3-Aminofuro[3,2-b]pyridin-2-yl)ethan-1-one (CAS 869789-21-9)
- Insulin Degludec Impurity 5 (CAS CATO-C4X-21575)
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