Baloxavir impurity 80 CAS 2136287-77-7
| CAS No. | 2136287-77-7 |
| Molecular Formula | C13H17N3O4 |
| Molecular Weight | 279.29 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Baloxavir impurity 80 (CAS 2136287-77-7) is a certified pharmaceutical impurity reference standard with the molecular formula C13H17N3O4 and a molecular weight of 279.29 g/mol.
The molecular framework of Baloxavir impurity 80 (C13H17N3O4) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H17N3O4 |
| Molecular Weight | 279.29 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Nitrogen Atoms | 3 |
Related Baloxavir Standards
- Baloxavir Marboxil Impurity 206 (CAS CATO-C4X-2108206)
- Baloxavir Marboxil Impurity 239 (CAS 1824026-96-1)
- Baloxavir Impurity 62 (CAS CATO-C4X-210862)
- Baloxavir Impurity 106 (CAS CATO-C4X-2108106)
- Baloxavir Impurity 17 (CAS 2136287-65-3)
- Baloxavir Marboxil Impurity 178 (CAS 2757707-17-6)
- Baloxavir Marboxil Impurity 188 (CAS CATO-C4X-2108188)
- Baloxavir Marboxil Impurity 189 (CAS CATO-C4X-2108189)
Recommended Standards
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- Fructose Valine (mixture of diastereomers) (CAS 10003-64-2)
- Lacosamide impurity 40 (CAS CATO-C4X-183040)
- Ezetimibe Impurity 24 (CAS 528565-93-7)
- Chlorphenamine Impurity 24 (CAS CATO-C4X-118824)
- Nemonoxacin Impurity 110 (CAS 221221-39-2（free base）)
- 4-Chloro-3-pyrrolidin-1-yl-benzoic acid (CAS 107946-68-9)
- 2,5-Dioxo-1-pyrrolidinyl 3-[2-[2-[2-(2,5-dioxo-2,5-dihydro-1-pyrrolyl)ethoxy]ethoxy]ethoxy]propanoate (CAS 1537892-36-6)
- 1,4,5,6,7,8-Hexahydroimidazo[4,5-d]azepine dihydrochloride (CAS 943722-25-6)
- 1,2,3,4,9-Pentabromodibenzo[b,d]furan (CAS 617707-96-7)
- n-(4-Aminocyclohexyl)-2-phenylacetamide (CAS 1154624-72-2)
- (4-oxazol-2-ylphenyl) acetate (CAS 943767-42-8)
- Tirzepatide Impurity 36 (CAS CATO-C4X-324036)
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