Ezetimibe Impurity 24 CAS 528565-93-7
| CAS No. | 528565-93-7 |
| Molecular Formula | C20H20FNO4 |
| Molecular Weight | 357.38 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Ezetimibe Impurity 24 (C20H20FNO4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a process- or degradation-related impurity, Ezetimibe Impurity 24 (CAS 528565-93-7, C20H20FNO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Ezetimibe Impurity 24 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H20FNO4 |
| Molecular Weight | 357.38 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Ezetimibe Standards
- Ezetimibe Impurity 125 (CAS 439080-96-3)
- Ezetimibe Impurity 139 (CAS CATO-C4X-1098139)
- Ezetimibe Impurity 25 (CAS 404874-94-8)
- Ezetimibe Impurity 26 (CAS 1612153-32-8)
- Ezetimibe Impurity 42 (CAS 189028-95-3)
- Ezetimibe Impurity 93 (CAS CATO-C4X-109893)
- Ezetimibe Impurity 36 (CAS 189028-93-1)
- Ezetimibe Impurity 38 (CAS 404874-93-7)
Recommended Standards
- Axitinib Impurity 77 (CAS CATO-C4X-107177)
- Axitinib Impurity 55 (CAS CATO-C4X-107155)
- Trelagliptin impurity 87 (CAS 2270843-82-6)
- Citalopram Impurity 75 (CAS CATO-C4X-110975)
- Amlodipine Impurity N15 (CAS 19532-97-9)
- Salbutamol Impurity 111 (CAS CATO-C4X-1176111)
- Paclitaxel Impurity 34 (CAS 71629-92-0)
- 9-Nitro-1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinoline (CAS 955096-23-8)
- 2-(4-Amino-1H-pyrrolo[3,2-c]pyridin-1-yl)-N,N-dimethylacetamide (CAS 494767-43-0)
- 1-(1,2-oxazol-5-ylmethyl)piperazine dihydrochloride (CAS 2060040-69-7)
- Methyl 2-amino-6,6-dimethyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (CAS 1340164-13-7)
- 13-(4-Bromobenzyl)-13H-indolo[3,2-c]acridine (CAS 860783-92-2)
- (6-(9,9-Dihexyl-9H-fluoren-2-yl)pyridin-3-yl)methanol (CAS 921754-95-2)
- Semaglutide impurity 27 (CAS CATO-C4X-222627)
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