3-[2-(Dimethylamino)Ethoxy]-1-[3-(Trifluoromethyl)Phenyl]-1H-Indazole CAS 21487-12-7
| CAS No. | 21487-12-7 |
| Molecular Formula | C18H18F3N3O |
| Molecular Weight | 349.35 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 3-[2-(Dimethylamino)Ethoxy]-1-[3-(Trifluoromethyl)Phenyl]-1H-Indazole is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
3-[2-(Dimethylamino)Ethoxy]-1-[3-(Trifluoromethyl)Phenyl]-1H-Indazole (CAS 21487-12-7), molecular formula C18H18F3N3O and molecular weight 349.35 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 3-[2-(Dimethylamino)Ethoxy]-1-[3-(Trifluoromethyl)Phenyl]-1H-Indazole (C18H18F3N3O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 3-[2-(Dimethylamino)Ethoxy]-1-[3-(Trifluoromethyl)Phenyl]-1H-Indazole under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C18H18F3N3O |
| Molecular Weight | 349.35 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
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Recommended Standards
- 3-(4-Ethylbenzenesulfonyl)-6,7-difluoro-1,4-dihydroquinolin-4-one (CAS 902298-06-0)
- 3-Morpholinomethyl-2-trifluoromethylbenzophenone (CAS 898791-95-2)
- 3-((2,5-Dimethylphenyl)sulfonyl)-6,7-difluoroquinolin-4(1H)-one (CAS 899348-49-3)
- 3-Morpholinomethyl-4-trifluoromethylbenzophenone (CAS 898792-01-3)
- 2,6-Dimethylphenyl 2-((3-cyano-4,6-diphenylpyridin-2-yl)thio)acetate (CAS 336173-47-8)
- 1-(2,4-Dimethoxyphenyl)cyclopropanecarboxamide (CAS 2006276-84-0)
- 2-(4-Ethylpiperazin-1-yl)-7-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbaldehyde (CAS 889996-84-3)
- Ethyl 4,7-difluoro-1H-indole-2-carboxylate (CAS 394223-44-0)
- 1-(3-Chloro-2-methylphenyl)-2,2,3,3,3-pentafluoropropan-1-one (CAS 1352210-01-5)
- (3-Methyl-1-(4-methylcyclohexyl)-1h-pyrazol-4-yl)methanamine (CAS 1339134-98-3)
- (4-Bromophenyl)(2,4,5-trimethylphenyl)methanol (CAS 1443351-84-5)
- 2-((3-Cyanothiophen-2-yl)amino)-2-oxoethyl 2-(3-(trifluoromethyl)phenyl)acetate (CAS 338777-44-9)
- 3-(5-Chloro-1-methyl-1H-benzo[d]imidazol-2-yl)propan-1-ol (CAS 1243551-71-4)
- D-Leu14-Tirzepatide (CAS CATO-CPTD788920)
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