2,6-Difluoro-4-hydroxybenzoic Acid CAS 214917-68-7
| CAS No. | 214917-68-7 |
| Molecular Formula | C7H4F2O3 |
| Molecular Weight | 174.10 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
2,6-Difluoro-4-hydroxybenzoic Acid (CAS 214917-68-7) is a high-purity analytical reference standard with the molecular formula C7H4F2O3 and a molecular weight of 174.10 g/mol.
The molecular framework of 2,6-Difluoro-4-hydroxybenzoic Acid (C7H4F2O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C7H4F2O3 |
| Molecular Weight | 174.10 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2018 |
| Halogen Content | F-containing |
Related Difluoro Standards
- 3,5-Difluoro-4-nitroaniline (CAS 122129-79-7)
- 2,4-Difluoro-5-nitroaniline (CAS 123344-02-5)
- 2,2-Difluoro-2-(pyrimidin-5-yl)acetic acid (CAS 1250738-18-1)
- 2,5-Difluoro-4-hydroxybenzoic acid (CAS 146781-23-9)
- 2,5-Difluoro-4-nitroaniline (CAS 1542-36-5)
- 2,5-Difluoro-3-nitroaniline (CAS 1699538-79-8)
- 2,3-Difluoro-4-hydroxybenzoic Acid (CAS 175968-39-5)
- 2,3-Difluoro-4-nitroaniline (CAS 1781140-23-5)
Recommended Standards
- 2,6-Difluoro-3-nitroaniline (CAS 25892-09-5)
- 2,6-Difluoro-4-nitroaniline (CAS 23156-27-6)
- 2,6-Difluoro-3-hydroxybenzoic acid (CAS 749230-32-8)
- 3,4-Difluoro-2-nitroaniline (CAS 292145-76-7)
- 3-(8-Carbamoyl-2,4-dimethylimidazo[1,5-a]pyrimidin-3-yl)propanoic acid (CAS 923727-79-1)
- n-(4-Cyanophenyl)-4-(4-methylphenoxy)butanamide (CAS 793692-57-6)
- 1-(1-Methyl-2-oxoindolin-5-yl)-3-phenylurea (CAS 1170298-85-7)
- (1S,2S)-2-(((((9H-fluoren-9-yl)methoxy)carbonyl)amino)methyl)cyclopropane-1-carboxylic acid (CAS 2196202-80-7)
- 8-Methyl-8-azabicyclo[3.2.1]octan-2-amine dihydrochloride (CAS 2306275-76-1)
- (R)-1-(5-Chlorothiophen-2-yl)ethan-1-ol (CAS 105026-71-9)
- N-[1-(5-{[(4-bromophenyl)methyl]sulfanyl}-4-methyl-4H-1,2,4-triazol-3-yl)-2-phenylethyl]-4-chlorobenzene-1-sulfonamide (CAS 338794-27-7)
- 2,4-Dichloro-3-methylaniline (CAS 19853-79-3)
- Tert-butyl N-(5-bromopentyl)-N-methylcarbamate (CAS 1694011-13-6)
- Semaglutide impurity 210 (CAS CATO-C4X-2226210)
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