Tert-butyl (6-chloro-4-(difluoromethyl)pyridin-3-yl)carbamate CAS 2149597-34-0
| CAS No. | 2149597-34-0 |
| Molecular Formula | C11H13ClF2N2O2 |
| Molecular Weight | 278.68 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Tert-butyl (6-chloro-4-(difluoromethyl)pyridin-3-yl)carbamate.
Tert-butyl (6-chloro-4-(difluoromethyl)pyridin-3-yl)carbamate (CAS 2149597-34-0), molecular formula C11H13ClF2N2O2 and molecular weight 278.68 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Tert-butyl (6-chloro-4-(difluoromethyl)pyridin-3-yl)carbamate (C11H13ClF2N2O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H13ClF2N2O2 |
| Molecular Weight | 278.68 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Recommended Standards
- 2-(4-Chlorophenyl)-3-(difluoromethyl)benzofuran (CAS 821769-99-7)
- 6-Chloro-N-(2-hydroxy-2-(pyridin-3-yl)ethyl)pyridazine-3-carboxamide (CAS 1024604-99-6)
- 5-Chloro-3-(2-(trifluoromethyl)benzyl)-1,2,4-thiadiazole (CAS 1338218-70-4)
- N-(5-(4-Chloro-2-hydroxyphenoxy)pyridin-2-yl)acetamide (CAS 1071966-42-1)
- N-[(2,6-dimethylimidazo[2,1-b][1,3]thiazol-5-yl)methyl]-N-methylamine dihydrochloride (CAS 1177362-23-0)
- m-Tolylacetyl chloride (CAS 13910-79-7)
- (S)-2-((Methoxycarbonyl)amino)butanoic acid (CAS 259874-14-1)
- 1-((3-Chlorobenzyl)oxy)-2-(4-chlorophenyl)-1H-imidazo[4,5-b]pyridine (CAS 339009-90-4)
- Ethyl 3-(chloromethyl)azetidine-3-carboxylate hydrochloride (CAS 1078166-36-5)
- N-[2-(4-Isopropylphenoxy)ethyl]-2,6-dimethylaniline (CAS 1040686-26-7)
- 4-Phenyl-3-furoxancarbonitrile (CAS 125520-62-9)
- Phenyl 8-methyl-2-phenylquinoline-4-carboxylate (CAS 355826-81-2)
- Ethyl 2-(2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)hydrazinyl)-2-oxoacetate (CAS 446276-05-7)
- Tirzepatide Impurity 13 (CAS CATO-C4X-324013)
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