2-(2-Chloro-5-(5-(difluoromethoxy)-1-methyl-1H-pyrazol-3-yl)-4-fluorophenoxy)-N-methylacetamide CAS 2151827-00-6
| CAS No. | 2151827-00-6 |
| Molecular Formula | C14H13ClF3N3O3 |
| Molecular Weight | 363.72 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-(2-Chloro-5-(5-(difluoromethoxy)-1-methyl-1H-pyrazol-3-yl)-4-fluorophenoxy)-N-methylacetamide (CAS 2151827-00-6), molecular formula C14H13ClF3N3O3 and molecular weight 363.72 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 2-(2-Chloro-5-(5-(difluoromethoxy)-1-methyl-1H-pyrazol-3-yl)-4-fluorophenoxy)-N-methylacetamide (C14H13ClF3N3O3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 363.72 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-(2-Chloro-5-(5-(difluoromethoxy)-1-methyl-1H-pyrazol-3-yl)-4-fluorophenoxy)-N-methylacetamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H13ClF3N3O3 |
| Molecular Weight | 363.72 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
- 5-Chloro-N-(2,5-dimethoxyphenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide (CAS 321533-85-1)
- 1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(prop-2-yn-1-yl)-1H-pyrrole-2-sulfonamide (CAS 338407-37-7)
- 5-(3-Chloro-4-methoxyphenyl)-N-(2,4-difluorophenyl)furan-2-carboxamide (CAS 853333-72-9)
- 3-(2-Chloro-6-fluorobenzyl)-1-((6-fluoropyridin-2-yl)amino)-4-hydroxypyridin-2(1H)-one (CAS 400077-42-1)
- 6-Chloro-N4-(3,4-dichlorobenzyl)-N2-methyl-5-(methylthio)pyrimidine-2,4-diamine (CAS 400074-35-3)
- N-(2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclohexanecarboxamide (CAS 2246655-25-2)
- (1E)-1-(5-Chloro-1-methyl-3-phenyl-1H-pyrazol-4-yl)-N-[3-(trifluoromethyl)phenyl]methanimine (CAS 320422-71-7)
- 8-Chloro-2-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-1,5-naphthyridine (CAS 2419129-92-1)
Recommended Standards
- Elexacaftor Impurity 2 (CAS 2229861-17-8)
- (E)-2-(ethylthio)-1-methyl-5-((2-(2,4,6-trichlorophenyl)hydrazono)methyl)-1H-imidazole (CAS 477845-49-1)
- tert-Butyl (3-chloro-4,5-bis(trifluoromethyl)phenyl)carbamate (CAS 2803283-48-7)
- 2-(4-Chlorophenyl)-2-oxoethyl 2-methyl-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate (CAS 339026-40-3)
- 5-Methyl-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine (CAS 1060803-13-5)
- 6-Fluoro-4-hydroxy-2-methyl-3-nitroquinoline (CAS 1203578-88-4)
- Ethyl 3-(2-methoxy-2-oxoethyl)-5-oxo-3-pyrrolidinecarboxylate (CAS 1823833-75-5)
- 6-(2-methylpropoxy)pyridin-3-amine (CAS 867131-50-8)
- Methyl 8-azabicyclo[3.2.1]octane-3-carboxylate (CAS 690952-61-5)
- IR-783 (CAS 115970-66-6)
- (R)-7-bromo-6-fluorochroman-4-ol (CAS 1568231-12-8)
- 2-(1-Adamantyl)-1H-indole (CAS 26845-72-7)
- (3-Iodo-4-nitrophenyl)methanol (CAS 1261794-62-0)
- Endo-Gly29-Tirzepatide (CAS CATO-CPTD788685)
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