6,7-Dimethoxy-4-piperazin-1-yl-quinazoline CAS 21584-72-5
| CAS No. | 21584-72-5 |
| Molecular Formula | C14H18N4O2 |
| Molecular Weight | 274.32 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
6,7-Dimethoxy-4-piperazin-1-yl-quinazoline (C14H18N4O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
6,7-Dimethoxy-4-piperazin-1-yl-quinazoline (CAS 21584-72-5), molecular formula C14H18N4O2 and molecular weight 274.32 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H18N4O2 |
| Molecular Weight | 274.32 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Nitrogen Atoms | 4 |
Related Dimethoxy Standards
- 6,7-Dimethoxy-2-(l-piperazinyl)-Quinazoline (CAS 104966-39-4)
- 2,3-Dimethoxy-6h,7h,8h,9h,10h,12h-azepino[2,1-b]quinazolin-12-one (CAS 475638-35-8)
- 3,3'-Dimethoxy-5,5'-dimethyl-[1,1'-biphenyl]-2,2'-diol (CAS 13990-86-8)
- 3,4-Dimethoxy-6-phenethylbenzene-1,2-diol (CAS 39354-56-8)
- Methyl 2,6-Dimethoxy-3-(methylsulfonyl)benzoate (CAS 2006276-95-3)
- 6,7-Dimethoxy-1-(pyrrolidin-1-ylmethyl)-3,4-dihydroisoquinoline (CAS 921213-21-0)
- 6,7-Dimethoxy-1-methyl-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxylic acid (CAS 1146292-94-5)
- 5,5-Dimethoxy-2-phenoxy-1,3,2-dioxaphosphorinane 2-Oxide (CAS 231280-23-2)
Recommended Standards
- 5-Methyl-1-phenyl-1H-pyrrolo[3,2-c]quinolin-4(5H)-one (CAS 88264-01-1)
- 6-Amino-1-benzyl-5-propylamino-1H-pyrimidine-2,4-dione (CAS 343346-91-8)
- 5-[4-(4-Methoxyphenyl)piperazin-1-yl]-1H-1,2,4-triazol-3-amine (CAS 339021-27-1)
- 6-Amino-2,4-diphenyl-1,4-dihydropyrimidine-5-carbonitrile (CAS 89068-96-2)
- 2-(Tert-butyl)-5-hydrazinylpyridine (CAS 848980-02-9)
- 1,3-Bis(chloromethyl)-5-nitrobenzene (CAS 862379-92-8)
- 1-Cyclopropanecarbonyl-9b-phenyl-1H,2H,3H,5H,9bH-imidazo[2,1-a]isoindol-5-one (CAS 338414-92-9)
- 1-Bromo-2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl acetate (CAS 89218-53-1)
- Ebastine Impurity N2 (CAS 43076-61-5)
- 2-Chloro-1-(3-chlorothiophen-2-yl)ethanone (CAS 62673-63-6)
- 1-(4-(4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-1H-1,2,3-triazol-1-yl)phenyl)ethan-1-one (CAS 478041-19-9)
- 2-(5-Furan-2-yl-3-trifluoromethyl-pyrazol-1-yl)-benzoic acid methyl ester (CAS 228259-40-3)
- 3-(4-Chloro-3,5-dimethyl-1h-pyrazol-1-yl)-2-(ethylamino)propanoic acid (CAS 1247154-09-1)
- Polymyxin B nonapeptide (CAS 86408-36-8)
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