Tert-butyl (S)-2-(difluoromethyl)piperazine-1-carboxylate CAS 2165338-39-4
| CAS No. | 2165338-39-4 |
| Molecular Formula | C10H18F2N2O2 |
| Molecular Weight | 236.26 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies Tert-butyl (S)-2-(difluoromethyl)piperazine-1-carboxylate (CAS 2165338-39-4), a certified reference material (molecular formula C10H18F2N2O2, MW 236.26 g/mol) for analytical method development and quality control.
Owing to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, Tert-butyl (S)-2-(difluoromethyl)piperazine-1-carboxylate is typically white to off-white crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 236.26 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H18F2N2O2 |
| Molecular Weight | 236.26 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Recommended Standards
- tert-Butyl (S)-(4,4-difluoropiperidin-3-yl)carbamate (CAS 2089321-16-2)
- Tert-butyl (S)-3-(difluoromethyl)piperazine-1-carboxylate (CAS 2166007-82-3)
- Tert-butyl (R)-4-(aminomethyl)-3,3-difluoropyrrolidine-1-carboxylate (CAS 2199215-01-3)
- Tert-butyl (S)-4-(aminomethyl)-3,3-difluoropyrrolidine-1-carboxylate (CAS 2380445-82-7)
- 2,3,4,5-Tetrafluoro-6-methoxybenzenesulfonyl chloride (CAS 2586111-78-4)
- (5-(tert-Butyl)isoxazol-4-yl)methanol (CAS 155602-41-8)
- 2-(Difluoromethyl)-6-fluoro-3-hydroxy-5-iodopyridine (CAS 1805483-00-4)
- 3-(4-Ethoxy-3-methoxyphenyl)-2-oxopropanoic acid (CAS 66488-86-6)
- 3-Chloro-2-{[5-(4-chlorobenzenesulfonyl)thiophen-2-yl]methyl}-5-(trifluoromethyl)pyridine (CAS 321430-96-0)
- 1-[(4-Fluorophenyl)methyl]-1H-pyrazol-5-amine (CAS 137968-28-6)
- Methyl 5-iodo-2-methylnicotinate (CAS 1211519-61-7)
- 1-(2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-3-propylurea (CAS 2246682-09-5)
- 2-(4-Aminophenoxy)benzonitrile (CAS 30202-91-6)
- Palmitoyl Hexapeptide-12 TFA salt (CAS 171263-26-6(Free Base))
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