3-chloro-2-[2-(trimethylsilyl)ethynyl]pyridine CAS 216979-76-9
| CAS No. | 216979-76-9 |
| Molecular Formula | C10H12ClNSi |
| Molecular Weight | 209.75 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-chloro-2-[2-(trimethylsilyl)ethynyl]pyridine.
3-chloro-2-[2-(trimethylsilyl)ethynyl]pyridine (CAS 216979-76-9), molecular formula C10H12ClNSi and molecular weight 209.75 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 3-chloro-2-[2-(trimethylsilyl)ethynyl]pyridine (C10H12ClNSi) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 209.75 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H12ClNSi |
| Molecular Weight | 209.75 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2018 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related chloro Standards
- 1034467-33-8 4-Chloro-3-((trimethylsilyl)ethynyl)pyridine 7779AC C10H12ClNSi (CAS 1034467-33-8)
- 5-Chloro-2-((trimethylsilyl)ethynyl)pyridine (CAS 132308-18-0)
- 2-chloro-4-[2-(trimethylsilyl)ethynyl]pyridine (CAS 499193-57-6)
- 3-Chloro-5-((trimethylsilyl)ethynyl)pyridine (CAS 329202-21-3)
- 1-(3-Chloro-4-methylphenyl)piperidine (CAS 1000339-31-0)
- 8-Chloro-2,2,4-trimethyl-1,2,3,4-tetrahydroquinoline (CAS 101948-16-7)
- 5-Chloro-N-(1-cyclopropylethyl)-2-methylaniline (CAS 1019581-44-2)
- 1-(3-Chloro-2-methylphenyl)piperidine (CAS 1020253-08-0)
Recommended Standards
- 5331-91-9 R9099U429R 5-Chloro-2-mercaptobenzothiazole 2-Benzothiazolethiol, 5-chloro- 2(3H)-Benzothiazolethione, 5-chloro- (9CI) Benzothiazole, 5-chloro-2-mercapto- 5-Chloro-2-benzothiazolethiol EINECS 226-235-0 NSC 3934 SH-Benzothiazole UNII-R9099U429R (CAS 5331-91-9)
- Indium(III) phosphate (CAS 14693-82-4)
- 1-(4-Chlorobenzyl)piperidine (CAS 59507-42-5)
- Lithium citrate (CAS 919-16-4)
- 5-Morpholinopyrazine-2-carboxylic acid (CAS 946598-39-6)
- 2-Bromo-3-fluorobenzeneboronic acid (CAS 731817-89-3)
- 2,3-dichlorobutane (CAS 7581-97-7)
- 3-((2-Methylbenzyl)thio)-1-phenyl-6,7-dihydro-5H-cyclopenta[c]pyridine-4-carbonitrile (CAS 439096-31-8)
- Mephenytoin Impurity 3 (CAS 50-12-4)
- 1-Benzoylisoquinoline (CAS 16576-23-1)
- N-(3-Amino-5-(hydroxymethyl)phenyl)methanesulfonamide (CAS 945397-40-0)
- 3-[3-(2-azidoethylamino)-2,5-dioxo-pyrrol-1-yl]piperidine-2,6-dione (CAS 2913241-66-2)
- Mecillinam (CAS 32887-01-7)
- Acetyl Tetrapeptide-5 (CAS 820959-17-9)
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