Baloxavir Impurity 138 CAS 2169849-55-0
| CAS No. | 2169849-55-0 |
| Molecular Formula | C15H13FO2S |
| Molecular Weight | 276.33 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Baloxavir Impurity 138 (CAS 2169849-55-0, C15H13FO2S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, a polycyclic aromatic system, Baloxavir Impurity 138 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 276.33 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Baloxavir Impurity 138 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H13FO2S |
| Molecular Weight | 276.33 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F-containing |
| Sulfur Atoms | 1 |
Related Baloxavir Standards
- Baloxavir Impurity 136 (CAS 2954948-34-4)
- Baloxavir Impurity 107 (CAS 2136287-64-2)
- Baloxavir Marboxil Impurity 158 (CAS CATO-C4X-2108158)
- Baloxavir Marboxil Impurity 216 (CAS CATO-C4X-2108216)
- Baloxavir Marboxil Impurity 226 (CAS CATO-C4X-2108226)
- Baloxavir Impurity 62 (CAS CATO-C4X-210862)
- Baloxavir Marboxil Impurity 201 (CAS CATO-C4X-2108201)
- Baloxavir Marboxil Impurity 239 (CAS 1824026-96-1)
Recommended Standards
- Anthanthrene (CAS 191-26-4)
- Revefenacin Impurity 38 (CAS 733783-20-5)
- Indeno[1,2,3-c,d]fluoranthene (CAS 193-43-1)
- Doxapram impurity 43 (CAS CATO-C4X-197343)
- Donepezil EP impurity F (CAS 145546-80-1)
- Prilocaine impurity 51 (CAS CATO-C4X-193451)
- Flucloxacillin EP Impurity D (CAS 3919-74-2)
- 2-Formylphenoxyacetic acid (CAS 6280-80-4)
- Tert-butyl 2-amino-6-methyl-4h,5h,6h,7h-thieno[2,3-c]pyridine-3-carboxylate (CAS 353467-24-0)
- (1,5-Diphenyl-1H-pyrazol-3-yl)methanol (CAS 945984-78-1)
- (R)-2-Amino-3-(2,6-difluorophenyl)propanoicacid (CAS 266360-62-7)
- Vinyl Methacrylate (stabilized with MEHQ) (CAS 4245-37-8)
- 2-((4-Nitrophenoxy)methyl)-1,3-dioxolane (CAS 179246-35-6)
- Semaglutide impurity 100 (CAS CATO-C4X-2226100)
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