Ruxolitinib Impurity 111 L-Tartrate CAS 2169914-36-5
| CAS No. | 2169914-36-5 |
| Molecular Formula | C8H14N2O |
| Molecular Weight | 304.30 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO supplies Ruxolitinib Impurity 111 L-Tartrate (CAS 2169914-36-5), a pharmacopoeial impurity reference standard (molecular formula C8H14N2OC4H6O6, MW 304.30 g/mol) used for the identification and quantification of trace impurities in APIs.
Ruxolitinib Impurity 111 L-Tartrate (C8H14N2OC4H6O6) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H14N2O C4H6O6 |
| Molecular Weight | 304.30 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Nitrogen Atoms | 2 |
Related Ruxolitinib Standards
- Ruxolitinib Impurity 79 (CAS 941678-60-0)
- Ruxolitinib Impurity 236 (CAS CATO-C4X-2058236)
- rac-Ruxolitinib (CAS 941688-05-7)
- Ruxolitinib Hemifumarate (CAS 2803478-47-7)
- Ruxolitinib (CAS 941678-49-5)
- Ruxolitinib Impurity 23 (CAS CATO-C4X-205823)
- (S)-Ruxolitinib (CAS 941685-37-6)
- Ruxolitinib Impurity N3 (CAS 1643967-75-2)
Recommended Standards
- Dexrazoxane Impurity 7 (CAS CATO-C4X-20207)
- 2-Naphthol-6,8-Disulfonic Acid (CAS 118-32-1)
- Dexrazoxane Impurity 6 (CAS CATO-C4X-20206)
- 2-Naphthol-3,6-disulfonic acid (CAS 148-75-4)
- Bexarotene Impurity 3 (CAS 2825537-35-5)
- Carteolol EP Impurity I (CAS 2748462-62-4)
- Methylprednisolone Impurity 69 (CAS CATO-C4X-191969)
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- 1,3-Cyclooctadiene 3806-59-5 ACMC-1CC5B (CAS 3806-59-5)
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- 5-(aminomethyl)-1,3,4-oxadiazol-2-amine dihydrochloride (CAS 89066-22-8)
- 1-chloro-2,2-dimethoxypropane (CAS 32730-70-4)
- 2-[(4-Bromophenyl)sulfanyl]-6-[3-(trifluoromethyl)phenyl]pyridine-3-carbonitrile (CAS 252060-02-9)
- (Des-Gly2)-Exenatide trifluoroacetate salt (CAS 1678416-78-8)
Why CATO?
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