3-(Trifluoromethyl)azetidine-1-sulfonyl chloride CAS 2172000-05-2
| CAS No. | 2172000-05-2 |
| Molecular Formula | C4H5ClF3NO2S |
| Molecular Weight | 223.60 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 3-(Trifluoromethyl)azetidine-1-sulfonyl chloride (C4H5ClF3NO2S) is characterized by an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
3-(Trifluoromethyl)azetidine-1-sulfonyl chloride (CAS 2172000-05-2) is a high-purity analytical reference standard with the molecular formula C4H5ClF3NO2S and a molecular weight of 223.60 g/mol.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 3-(Trifluoromethyl)azetidine-1-sulfonyl chloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C4H5ClF3NO2S |
| Molecular Weight | 223.60 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 1.0 |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
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Recommended Standards
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- 3-(3-Chloro-phenyl)-isoxazole-5-carboxylic acid (CAS 100517-43-9)
- 2-(Chloromethyl)-4-(difluoromethyl)-3-hydroxy-5-methoxypyridine (CAS 1807001-79-1)
- 5-(4-Chlorophenyl)oxazole-2-carboxylic Acid (CAS 1017-03-4)
- Benzyl (2-(1H-indol-3-yl)ethyl)carbamate (CAS 38750-13-9)
- 3-Methyl-N-(5-(propylthio)-1,3,4-thiadiazol-2-yl)butanamide (CAS 393565-23-6)
- Cyclohexane, ethenyl-, homopolymer (CAS 25498-06-0)
- n-(Piperidin-4-ylmethyl)-3-(trifluoromethyl)pyridin-2-amine hydrochloride (CAS 2680615-65-8)
- 5,6-Dichloro-1H-pyrrolo[2,3-b]pyridine (CAS 1190317-72-6)
- 2,6-Dichloro-N-(2,2,4-trimethyl-2,3-dihydrobenzofuran-7-yl)benzamide (CAS 866151-59-9)
- 5-(Boc-amino)pyridine-3-boronic Acid Pinacol Ester (CAS 1171897-39-4)
- 3-Bromo-5-(tert-butyl)isoxazole (CAS 1780726-89-7)
- Hexahydro-1H-cyclopenta[c]furan-1-carboxylic acid (CAS 1803562-54-0)
- Compstatin control peptide (CAS 301544-78-5)
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