3-Chloro-4-cyanophenyl Isothiocyanate CAS 21724-83-4
| CAS No. | 21724-83-4 |
| Molecular Formula | C8H3ClN2S |
| Molecular Weight | 194.64 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
3-Chloro-4-cyanophenyl Isothiocyanate (CAS 21724-83-4), molecular formula C8H3ClN2S and molecular weight 194.64 g/mol, is a CATO reference standard with documented purity and traceability.
3-Chloro-4-cyanophenyl Isothiocyanate (C8H3ClN2S) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H3ClN2S |
| Molecular Weight | 194.64 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Chloro Standards
- 4-Chloro-2-cyanophenylisothiocyanate (CAS 104615-78-3)
- 5-chloro-6-fluoro-pyrazolo[1,5-a]pyrimidin-7-amine (CAS 1610021-35-6)
- 3-Chloro-4-isothiocyanatobenzonitrile (CAS 402714-30-1)
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Recommended Standards
- 3,5-Dimethyl-1H-pyrazole-4-sulfonyl chloride (CAS 80466-78-0)
- 2-Chlorobenzothiazole-6-carbonitrile (CAS 80945-83-1)
- 3-Chlorothieno[2,3-b]pyridine-2-carbonitrile (CAS 72832-31-6)
- 2-Chlorobenzo[d]thiazole-5-carbonitrile (CAS 385432-46-2)
- 2-({7-methyl-4-oxo-1h,2h,3h,4h-cyclopenta[c]chromen-9-yl}oxy)acetic acid (CAS 307549-54-8)
- tert-Butyl 2-iodo-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate (CAS 1613148-20-1)
- 4-Fluoro-N-(2-methoxyphenyl)benzamide (CAS 301228-21-7)
- Boc-D-Glu-OMe (CAS 55227-00-4)
- 1-Butanol, 4-(decyloxy)- (CAS 97209-97-7)
- 2-(((4-Chlorophenyl)sulfonyl)methyl)pyrrolidine hydrochloride (CAS 1353989-68-0)
- Menaquinone Impurity 50 (CAS CATO-C4X-207650)
- (S)-7-Chloro-N-(quinucliDin-3-yl)Benzo[b]thiophene-2-carboxamide (CAS 766505-28-6)
- 6-Chloro-N,N-bis(2-chloroethyl)-5-nitropyrimidin-4-amine (CAS 54413-39-7)
- Semaglutide impurity 36 (CAS CATO-C4X-222636)
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