Bendamustine Ether Impurity (HCl) CAS 2173004-95-8
| CAS No. | 2173004-95-8 |
| Molecular Formula | C16H21N3O3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Bendamustine Ether Impurity (HCl) is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 339.82 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Bendamustine Ether Impurity (HCl) (CAS 2173004-95-8) is a certified pharmaceutical impurity reference standard with the molecular formula C16H21N3O3HCl and a molecular weight of 339.82 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Bendamustine Ether Impurity (HCl) meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H21N3O3 HCl |
| Molecular Weight | 339.82 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Bendamustine Standards
- Bendamustine impurity 33 (CAS 109882-25-9)
- Bendamustine Impurity 2 (CAS 109882-26-0)
- Bendamustine USP Related Compound E (CAS 109882-27-1)
- Bendamustine Dihydroxy Impurity (CAS 109882-29-3)
- Bendamustine USP Related Compound A (CAS 109882-30-6)
- Bendamustine-D8 Hydrochloride (CAS 1134803-33-0)
- Bendamustine Impurity 7 (CAS 1138238-08-0)
- Bendamustine Dideschloroethyl Acid Hydrochloride (CAS 1179363-38-2)
Recommended Standards
- Lenvatinib Impurity 34 (CAS 417721-34-7)
- Aztreonam impurity 59 (CAS CATO-C4X-152259)
- Cinitapride Impurity N30 (CAS 86718-16-3)
- [2,2,2]-Paracyclophane (CAS 283-80-7)
- 1,5-Dimethyl-4-nitroimidazole (CAS 7464-68-8)
- C188-9 (CAS 432001-19-9)
- (Z)-tert-Butyl 2-(((1-(2-aminothiazol-4-yl)-2-ethoxy-2-oxoethylidene)amino)oxy)-2-methylpropanoate (CAS 86299-46-9)
- Prednisone Impurity 29 (20(R)-Hydroxy Methylprednisolone) (CAS 387-65-5)
- 1-Isobutyryltetrahydropyrimidin-2(1H)-one (CAS 127834-94-0)
- Semaglutide Impurity 163 (x TFA Salt) (CAS CATO-C4X-2226163)
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