Prednisone Impurity 29 (20(R)-Hydroxy Methylprednisolone) CAS 387-65-5
| CAS No. | 387-65-5 |
| Molecular Formula | C22H32O5 |
| Molecular Weight | 376.49 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Prednisone Impurity 29 (20(R)-Hydroxy Methylprednisolone) is closely related to a flavonoid core, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Prednisone Impurity 29 (20(R)-Hydroxy Methylprednisolone) (CAS 387-65-5) is a high-purity analytical reference standard with the molecular formula C22H32O5 and a molecular weight of 376.49 g/mol.
Prednisone Impurity 29 (20(R)-Hydroxy Methylprednisolone) (C22H32O5) contains a flavonoid core, a hydroxyl group, an ether linkage. The carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Prednisone Impurity 29 (20(R)-Hydroxy Methylprednisolone) meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H32O5 |
| Molecular Weight | 376.49 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
Related Prednisone Standards
- Prednisone Impurity 28 (20(S)-Hydroxy Methylprednisolone) (CAS 387-66-6)
- Prednisone Impurity 14 (CAS 94088-91-2)
- Prednisone Impurity 5 (CAS 215095-77-5)
- Prednisone Impurity 12 (CAS CATO-C4X-169412)
- Prednisone Impurity N56 (CAS 103466-44-0)
- Prednisone Impurity N297 (CAS 1249-67-8)
- Prednisone Impurity 14 (CAS CATO-C4X-169414)
- Prednisone-d8 (CAS CATO-C4X-191927)
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