Dapagliflozin Impurity 16 CAS 21739-92-4
| CAS No. | 21739-92-4 |
| Molecular Formula | C7H4BrClO2 |
| Molecular Weight | 235.46 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Dapagliflozin Impurity 16 is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine/bromine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Dapagliflozin Impurity 16 (CAS 21739-92-4) is a certified pharmaceutical impurity reference standard with the molecular formula C7H4BrClO2 and a molecular weight of 235.46 g/mol.
The molecular framework of Dapagliflozin Impurity 16 (C7H4BrClO2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine/bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H4BrClO2 |
| Molecular Weight | 235.46 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | Cl/Br-containing |
Related Dapagliflozin Standards
- Dapagliflozin Impurity 159 (CAS 936-08-3)
- Dapagliflozin Impurity N24 (CAS 42860-10-6)
- Dapagliflozin Impurity 8 (CAS 1662702-90-0)
- Dapagliflozin Impurity 102 (CAS CATO-C4X-1138102)
- Dapagliflozin Impurity 55 (CAS CATO-C4X-113855)
- Dapagliflozin Impurity N50 (CAS 21900-52-7)
- Dapagliflozin Impurity 153 (CAS 35672-52-7)
- Dapagliflozin Impurity 93 (CAS 525561-43-7)
Recommended Standards
- 2-Bromo-5-chlorobenzoic acid (CAS 21739-93-5)
- 3-Bromo-2-chlorobenzoic Acid (CAS 56961-27-4)
- Bromochlorobenzoic acid (CAS 25638-14-6)
- 2-Bromo-6-chlorobenzoic Acid (CAS 93224-85-2)
- Ceritinib Impurity 38 (CAS CATO-C4X-104838)
- Thiamine Nitrate EP Impurity D (CAS 490-82-4)
- Brivaracetam Impurity 113 (CAS CATO-C4X-2007113)
- 1-((4-Chlorobenzyl)sulfonyl)-2-(3,4-dichlorophenyl)propan-2-ol (CAS 339276-79-8)
- 4-(1,3-Dithiolan-2-yl)-2-methoxy-6-nitrophenyl 2-chlorobenzoate (CAS 298215-45-9)
- 4,6-Dichloro-2-methyl-1H-pyrrolo[2,3-b]pyridine (CAS 1352394-46-7)
- tert-Butyl 7-fluoro-3-oxa-9-azabicyclo[3.3.1]nonane-9-carboxylate (CAS 1998215-92-1)
- 4-Hydroxy-2,5-dimethylbenzoic Acid (CAS 27021-04-1)
- 6-Amino-5-cinnamoyl-1,3-dimethylpyrimidine-2,4(1H,3H)-dione (CAS 74838-72-5)
- Macrocyclic Peptide flaviviridae Viruses InhibitorDISCONTINUED (CAS 1510841-23-2)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com