Dapagliflozin Impurity N50 CAS 21900-52-7
| CAS No. | 21900-52-7 |
| Molecular Formula | C7H3BrCl2 |
| Molecular Weight | 253.91 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Dapagliflozin Impurity N50 (C7H3BrCl2) is characterized by chlorine/bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a process- or degradation-related impurity, Dapagliflozin Impurity N50 (CAS 21900-52-7, C7H3BrCl2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H3BrCl2 |
| Molecular Weight | 253.91 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1963 |
| Halogen Content | Cl/Br-containing |
Related Dapagliflozin Standards
- Dapagliflozin Impurity 102 (CAS CATO-C4X-1138102)
- Dapagliflozin Impurity 55 (CAS CATO-C4X-113855)
- Dapagliflozin Impurity 93 (CAS 525561-43-7)
- Dapagliflozin Impurity 8 (CAS 1662702-90-0)
- Dapagliflozin Impurity 49 (CAS 1408077-50-8)
- Dapagliflozin Impurity 74 (CAS 5032-11-1)
- Dapagliflozin Impurity 204 (CAS CATO-C4X-1138204)
- Dapagliflozin Impurity 159 (CAS 936-08-3)
Recommended Standards
- 6-Bromo-2,3-dichlorobenzaldehyde (CAS 945999-86-0)
- 2-Bromo-5-(2-bromoethyl)furan (CAS 1341531-02-9)
- 4-Bromo-3-chlorobenzoyl chloride (CAS 21900-32-3)
- 3,5-Dibromo-1,4-dimethyl-1H-pyrazole (CAS 134589-54-1)
- Dapagliflozin Impurity 76 (CAS 604-69-3)
- Cefcapene Impurity 86 (CAS 2165460-37-5)
- Ledipasvir Impurity 19 (CAS CATO-C4X-331319)
- 3-(4-Methoxyphenyl)-N-methylimidazo[1,2-a]pyrazin-8-amine (CAS 787591-14-4)
- Epinephrine /Adrenaline Impurity 121 (CAS CATO-C4X-1849121)
- 2-(3-Formyl-1H-indol-1-yl)-N-(2-methoxy-5-nitrophenyl)acetamide (CAS 886499-34-9)
- Acid Red 26 (CAS 3761-53-3)
- 2-((4-Chlorobenzyl)thio)-8,9,13b,14-tetrahydro-6H-[1,2,4]triazolo[5'',1'':2',3']pyrimido[4',5':4,5]pyrido[2,1-a]isoquinolin-6-one (CAS 344262-99-3)
- 5-(2-Hydroxyphenyl)-2,4-dihydro-3h-pyrazol-3-one (CAS 5186-66-3)
- Tirzepatide Impurity 48 (CAS CATO-C4X-324048)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com