Rivaroxaban Impurity 141 CAS 2174916-16-4
| CAS No. | 2174916-16-4 |
| Molecular Formula | C10H14N2O3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 246.69 g/mol gives Rivaroxaban Impurity 141 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Rivaroxaban Impurity 141 (CAS 2174916-16-4) is a certified pharmaceutical impurity reference standard with the molecular formula C10H14N2O3HCl and a molecular weight of 246.69 g/mol.
Rivaroxaban Impurity 141 (C10H14N2O3HCl) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H14N2O3 HCl |
| Molecular Weight | 246.69 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Rivaroxaban Standards
- Rivaroxaban Impurity 96 (CAS 1007650-38-5)
- Rivaroxaban Impurity 57 (CAS 1082495-22-4)
- Rivaroxaban Impurity 47 (CAS 1082588-73-5)
- Rivaroxaban-d4 (CAS 1132681-38-9)
- Rivaroxaban Impurity 74 (CAS 113471-08-2)
- Rivaroxaban EP Impurity I (CAS 1151893-81-0)
- Rivaroxaban 3-Hydroxy Metabolite (CAS 1159977-46-4)
- Rivaroxaban Impurity 15 (Mixture of Diastereomers) (CAS 1160169-99-2)
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- 3-Bromo-5-fluorophenylacetonitrile, 97% (CAS 305800-58-2)
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- 2-(4-(4-Fluorophenyl)-2-methyl-5-oxo-2,5-dihydro-1H-pyrazol-3-yl)-N-isopropylthiazole-4-carboxamide (CAS 914287-34-6)
- Dulaglutide (CAS 923950-08-7)
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