4-Chloro-7-(difluoromethyl)quinoline-3-carbonitrile CAS 2188210-72-0
| CAS No. | 2188210-72-0 |
| Molecular Formula | C11H5ClF2N2 |
| Molecular Weight | 238.62 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
4-Chloro-7-(difluoromethyl)quinoline-3-carbonitrile (CAS 2188210-72-0), molecular formula C11H5ClF2N2 and molecular weight 238.62 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-Chloro-7-(difluoromethyl)quinoline-3-carbonitrile (C11H5ClF2N2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
CATO manufactures 4-Chloro-7-(difluoromethyl)quinoline-3-carbonitrile under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C11H5ClF2N2 |
| Molecular Weight | 238.62 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 2-[4-chloro-3-(difluoromethyl)-5-methyl-1h-pyrazol-1-yl]propanoic acid (CAS 1005584-35-9)
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- 6-Chloro-3-methyl-4-oxo-4H-chromene-2-carboxylic Acid (CAS 1239779-74-8)
- 4-(3-Chloro-2,4-difluorophenyl)-1H-pyrrole-3-carbonitrile (CAS 124185-27-9)
- 4-Chloro-2-(trifluoromethyl)thieno[3,2-d]pyrimidine (CAS 147972-27-8)
- Ethyl 4-chloro-1-(2,2-difluoroethyl)-1H-pyrazole-3-carboxylate (CAS 1856061-98-7)
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Recommended Standards
- 4-Chloro-5-(trifluoromethyl)thieno[2,3-d]pyrimidine (CAS 917909-58-1)
- 5-(Chlorosulfonyl)-2-fluorobenzoic Acid (CAS 37098-75-2)
- 4-Chloro-3-(fluorosulfonyl)benzoic acid (CAS 2494-80-6)
- 6-Chloro-4-hydroxy-7-methyl-2-oxo-2H-chromene-3-carbaldehyde (CAS 925005-58-9)
- 5-((2H-Chromen-3-yl)methylene)-2-(4-propoxyphenyl)thiazolo[3,2-b][1,2,4]triazol-6(5H)-one (CAS 606962-49-6)
- 52089-55-1 Ethyl 2-hydroxyhexanoate EINECS 257-655-2 (CAS 52089-55-1)
- ethyl 3-carbamoyl-6-(3-hydroxypropyl)pyrazolo[1,5-a]pyrimidine-7-carboxylate (CAS 1146290-33-6)
- Didanosine EP Impurity D (CAS 13146-72-0)
- 2-(3-Nitropyridin-2-yl)acetonitrile (CAS 123846-65-1)
- Ethyl 3-oxo-1,2,3,4-tetrahydroquinoxaline-6-carboxylate (CAS 1353500-82-9)
- 4-Ethyl-7-hydroxyisobenzofuran-1(3H)-one (CAS 62596-60-5)
- N-Desmethyl Asenapine Hydrochloride (CAS 1170701-78-6)
- 2-((4-Fluorobenzyl)thio)-3-(2-hydroxypropyl)thieno[3,2-d]pyrimidin-4(3H)-one (CAS 1788585-53-4)
- Semaglutide impurity 59 (CAS CATO-C4X-222659)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com