Regorafenib Impurity 6 CAS 2188236-16-8
| CAS No. | 2188236-16-8 |
| Molecular Formula | C21H16F4N4O3 |
| Molecular Weight | 448.37 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Regorafenib Impurity 6 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Regorafenib Impurity 6 (CAS 2188236-16-8) is a certified pharmaceutical impurity reference standard with the molecular formula C21H16F4N4O3 and a molecular weight of 448.37 g/mol.
The molecular framework of Regorafenib Impurity 6 (C21H16F4N4O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Regorafenib Impurity 6 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C21H16F4N4O3 |
| Molecular Weight | 448.37 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Regorafenib Standards
- Regorafenib Impurity 56 (CAS CATO-C4X-104756)
- Regorafenib Impurity 15 (CAS 1343498-72-5)
- Regorafenib Impurity 4 (CAS 1187945-05-6)
- Regorafenib Impurity 60 (CAS CATO-C4X-104760)
- Regorafenib Impurity 78 (CAS CATO-C4X-104778)
- Regorafenib (CAS 755037-03-7)
- Regorafenib Impurity 52 (CAS CATO-C4X-104752)
- Regorafenib Impurity 7 (CAS CATO-C4X-10477)
Recommended Standards
- Enzalutamide Impurity 3 (CAS 1242137-18-3)
- 4-(3,4-Dihydroxyphenyl)-7-hydroxy-5-(((3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)chroman-3-one (CAS 116329-89-6)
- Ethyl 6-bromo-5-hydroxy-1-methyl-2-(3-(phenylthio)propyl)-1H-indole-3-carboxylate (CAS 1704066-69-2)
- Naringenin 4'-O-β-D-Glucuronide(Mixture of Diastereomers)Discontinued. Please see N379010. (CAS 1237479-04-7)
- Caspofungin Impurity Triflate Salt (CAS 1201042-11-6)
- Elagolix Impurity 113 (CAS CATO-C4X-2068113)
- Levosimendan Impurity 27 (CAS CATO-C4X-130827)
- (5-Bromo-2-ethylphenyl)methanol (CAS 1427385-06-5)
- Cabergoline Impurity 8 (CAS CATO-C4X-27748)
- 4-Benzoylphthalic Acid (CAS 3885-88-9)
- Ethyl 1-(4-acetylphenyl)-1H-pyrazole-3-carboxylate (CAS 2108488-92-0)
- (5-Methyl-2-(p-tolyl)-1H-imidazol-4-yl)methanol (CAS 62229-99-6)
- N-(3,4-Dimethylphenyl)-3-(3-methylphenyl)-2-(2H-1,2,3,4-tetrazol-5-yl)propanamide (CAS 483993-86-8)
- Liraglutide Impurity 6 TFA Salt (CAS CATO-C4X-19926)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com