Empagliflozin Impurity 111 CAS 2194590-02-6
| CAS No. | 2194590-02-6 |
| Molecular Formula | C17H16ClIO2 |
| Molecular Weight | 414.67 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Empagliflozin Impurity 111 (C17H16ClIO2) contains a steroid core, a hydroxyl group, an ether linkage, chlorine/iodine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a process- or degradation-related impurity, Empagliflozin Impurity 111 (CAS 2194590-02-6, C17H16ClIO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Empagliflozin Impurity 111 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C17H16ClIO2 |
| Molecular Weight | 414.67 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | Cl/I-containing |
Related Empagliflozin Standards
- Empagliflozin Impurity 113 (CAS 2452301-16-3)
- Empagliflozin Impurity 21 (CAS CATO-C4X-106521)
- Empagliflozin impurity 61 (CAS CATO-C4X-1065261)
- Empagliflozin impurity 265 (CAS CATO-C4X-1065265)
- Empagliflozin impurity 320 (CAS CATO-C4X-1065320)
- Empagliflozin Impurity 41 (CAS CATO-C4X-106541)
- Empagliflozin Impurity 50 (CAS 915095-94-2)
- Empagliflozin Impurity 64 (CAS CATO-C4X-106564)
Recommended Standards
- 6-Oxo-6-((2,7,8-trichlorodibenzo[b,d]furan-4-yl)amino)hexanoic acid (CAS 93943-02-3)
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- 5-(3-Chloro-4-((2,4-dichlorobenzyl)oxy)-5-ethoxyphenyl)-1,3,4-oxadiazol-2-amine (CAS 1706452-81-4)
- 1,1,6,6-Tetra(thiophen-2-yl)hexane (CAS 1228246-25-0)
- Regorafenib Impurity 78 (CAS CATO-C4X-104778)
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- Biapenem impurity 9 (CAS CATO-C4X-22739)
- Dabigatran Impurity 43 (CAS 212322-77-5)
- 5-Bromo-2-(2-fluorophenyl)-1H-indole (CAS 1188240-91-6)
- Ethyl 4-(2-((tert-butoxycarbonyl)(methyl)amino)-1-phenylethoxy)-2-(methylthio)pyrimidine-5-carboxylate (CAS 1255701-57-5)
- N-(6-amino-1-benzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-chloro-N-(2-methoxyethyl)acetamide (CAS 568555-81-7)
- Ethyl (3-chlorophenyl)glycinate (CAS 2573-31-1)
- 2,3,3A,4,5,6-hexahydro-1h-benz[de]isoquinoline (CAS 71960-94-6)
- Acetyl-Tau Peptide (244-274) (Repeat 1 Domain) trifluoroacetate salt (CAS 2022956-56-3)
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