Regorafenib Impurity 78 CAS CATO-C4X-104778
| CAS No. | CATO-C4X-104778 |
| Molecular Formula | C15H8Cl2F6N2O |
| Molecular Weight | 417.13 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Regorafenib Impurity 78 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Regorafenib Impurity 78 (CAS CATO-C4X-104778, C15H8Cl2F6N2O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Regorafenib Impurity 78 (C15H8Cl2F6N2O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 417.13 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C15H8Cl2F6N2O |
| Molecular Weight | 417.13 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Regorafenib Standards
- Regorafenib Impurity 60 (CAS CATO-C4X-104760)
- Regorafenib Impurity 73 (CAS CATO-C4X-104773)
- Regorafenib Impurity 53 (CAS CATO-C4X-104753)
- Regorafenib EP Impurity C (CAS 1855006-12-0)
- Regorafenib Impurity 38 (CAS CATO-C4X-104738)
- Regorafenib Impurity 6 (CAS 2188236-16-8)
- Regorafenib Impurity 56 (CAS CATO-C4X-104756)
- Regorafenib Impurity 41 (CAS CATO-C4X-104741)
Recommended Standards
- N-(2-chloro-5-(trifluoromethyl)phenyl)-2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)acetamide (CAS 477890-21-4)
- 索拉非尼杂质9 (CAS 370-50-3)
- 2-Amino-6-borono-2-(1-(2,4-dichlorobenzyl)piperidin-4-yl)hexanoic acid (CAS 1345810-21-0)
- 4-Bromo-N-(4-bromophenyl)-N-(p-tolyl)aniline (CAS 100308-67-6)
- Imipenem Impurity 5 (CAS CATO-C4X-16625)
- Bendamustine Impurity N20 (CAS 1219709-86-0)
- Dalbavancin Impurity 33 (CAS CATO-C4X-160233)
- Ethyl 5-cyano-2-(1,4-diazepan-1-yl)-6-methylnicotinate (CAS 683274-44-4)
- N-benzyl-3-chlorobenzamide (CAS 82082-49-3)
- Tert-butyl 9-(2-ethoxy-2-oxoethylidene)-3-azaspiro[5.5]Undecane-3-carboxylate (CAS 1416176-18-5)
- (3R,4S)-4-amino-6-bromochroman-3-ol (CAS 1373215-22-5)
- Methyl 2-amino-5-((3-(trifluoromethyl)pyridin-2-yl)oxy)benzoate hydrochloride (CAS 1007374-53-9)
- N-(4-acetylphenyl)-2-ethylbutanamide (CAS 425686-03-9)
- Semaglutide impurity 97 (CAS CATO-C4X-222697)
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