Benzydamine EP Impurity B HCl CAS 2196183-71-6
| CAS No. | 2196183-71-6 |
| Molecular Formula | C26H29N3O |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Benzydamine EP Impurity B HCl.
CATO supplies Benzydamine EP Impurity B HCl (CAS 2196183-71-6), a pharmacopoeial impurity reference standard (molecular formula C26H29N3OHCl, MW 436.00 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Benzydamine EP Impurity B HCl (C26H29N3OHCl) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C26H29N3O HCl |
| Molecular Weight | 436.00 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Benzydamine Standards
- Benzydamine Impurity 9 (CAS 100922-96-1)
- Benzydamine-d6 Hydrochloride (CAS 1246817-20-8)
- Benzydamine-d6 N-Oxide (CAS 1246820-03-0)
- Benzydamine Impurity D Hydrochloride (CAS 1281-00-1)
- Benzydamine Hydrochloride (CAS 132-69-4)
- Benzydamine Hydrochloride EP Impurity D (CAS 1337966-15-0)
- Benzydamine EP Impurity A HCl (CAS 2196185-65-4)
- Benzydamine EP Impurity C (CAS 2215-63-6)
Recommended Standards
- Lamivudine Impurity 1 (CAS 1235712-40-9)
- Amlodipine Impurity N5 (CAS 107812-86-2)
- Cefathiamidine Impurity 6 (CAS 905712-22-3)
- N-[4-(tert-Butyl)benzyl]-3-(3-phenylpropoxy)-aniline (CAS 1040690-48-9)
- (E)-N'-(5-bromopyridin-2-yl)-N,N-dimethylformimidamide (CAS 138888-98-9)
- 2-[(2-Methyl-1,3-dioxolan-2-yl)methyl]isoindole-1,3-dione (CAS 1775-18-4)
- methyl 6-{[({tert}-butoxycarbonyl)amino]methyl}nicotinate (CAS 384831-57-6)
- 2-chloro-1-(piperazin-1-yl)ethan-1-one, trifluoroacetic acid (CAS 1188914-95-5)
- Kr-<SUP>83</SUP>Kr (CAS 13965-98-5)
- Influenza PR8 Hemagglutinin Peptide (110-119) (H-6312.0005) (CAS 132031-50-6)
Why CATO?
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