Lidocaine EP Impurity C CAS 2198-53-0
| CAS No. | 2198-53-0 |
| Molecular Formula | C10H13NO |
| Molecular Weight | 163.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Lidocaine EP Impurity C (CAS 2198-53-0, C10H13NO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Lidocaine EP Impurity C (C10H13NO) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. Its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C10H13NO |
| Molecular Weight | 163.22 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 1 |
Related Lidocaine Standards
- Lidocaine Impurity 57 (CAS 102878-74-0)
- Lidocaine Impurity 87 (CAS CATO-C4X-167987)
- Lidocaine Impurity 45 (CAS 89-58-7)
- Lidocaine Impurity 49 (CAS 81-20-9)
- Lidocaine Impurity 14 (CAS 2315-36-8)
- Lidocaine Impurity 88 (CAS 1903300-52-6)
- Lidocaine Impurity 34 (CAS 29183-14-0)
- Lidocaine Impurity 50 (CAS 27794-54-3)
Recommended Standards
- Glipizide Impurity 15 (CAS 877-95-2)
- Prilocaine Impurity 13 (CAS 19343-15-8)
- Pioglitazone Impurity 14 (CAS 1526933-30-1)
- Primidone EP Impurity C (CAS 90-26-6)
- Finasteride Impurity 46 (CAS 158870-10-1)
- Sitagliptin Impurity 78-d4 (CAS 2892260-32-9 (unlabelled))
- Apalutamide Impurity 67 (CAS CATO-C4X-274967)
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