Apalutamide Impurity 67 CAS CATO-C4X-274967
| CAS No. | CATO-C4X-274967 |
| Molecular Formula | C16H8F6N6O |
| Molecular Weight | 414.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Apalutamide Impurity 67 (CAS CATO-C4X-274967) is a certified pharmaceutical impurity reference standard with the molecular formula C16H8F6N6O and a molecular weight of 414.26 g/mol.
The molecular framework of Apalutamide Impurity 67 (C16H8F6N6O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H8F6N6O |
| Molecular Weight | 414.26 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 6 |
Related Apalutamide Standards
- Apalutamide Impurity 100 (CAS CATO-C4X-2749100)
- Apalutamide Impurity 65 (CAS CATO-C4X-274965)
- Apalutamide Impurity 36 (CAS CATO-C4X-274936)
- Apalutamide Impurity 110 (CAS CATO-C4X-2749110)
- Apalutamide Impurity 111 (CAS CATO-C4X-2749111)
- Apalutamide Impurity 30 (CAS CATO-C4X-274930)
- Apalutamide Impurity 23 (CAS CATO-C4X-274923)
- Apalutamide Impurity 74 (CAS CATO-C4X-274974)
Recommended Standards
- 4-Bromo-N-(9-oxo-9H-fluoren-1-yl)benzene-1-sulfonamide (CAS 866155-11-5)
- N-((4-bromophenyl)sulfonyl)-N-(4-ethoxyphenyl)glycine (CAS 401602-95-7)
- Dotinurad Impurity 237 (CAS CATO-C4X-2494237)
- 3-(2,6-Dichlorophenyl)-N-[2-(1H-indol-3-yl)ethyl]-5-methyl-1,2-oxazole-4-carboxamide (CAS 1020252-50-9)
- Diltiazem Impurity 9 (CAS 116050-35-2)
- Retigabine Impurity 3 (CAS 1263404-73-4)
- Ethacridine Lactate Impurity 4 (CAS CATO-C4X-26094)
- 2,3-Dibromo-4-fluorobenzenesulfonyl chloride (CAS 1804931-89-2)
- 2-(Aminomethyl)-1-cyclobutylbutan-1-ol (CAS 1489699-68-4)
- 3-Methyl-4H-benzo[b][1,4]thiazine-2-carboxylic acid (CAS 446829-73-8)
- pyridine-2,3-diol (CAS 84719-32-4)
- 2,3-Dimethyl-1H-pyrrolo[3,2-c]pyridin-4(5H)-one (CAS 878232-87-2)
- 5-(4-Bromophenyl)-2-methyl-1,3-thiazole-4-carboxylic acid (CAS 1038509-06-6)
- Semaglutide238 (CAS CATO-C4X-2226238)
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