Bilastine Impurity 40 CAS 2199440-16-7
| CAS No. | 2199440-16-7 |
| Molecular Formula | C12H15ClO2 |
| Molecular Weight | 226.70 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system, Bilastine Impurity 40 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 226.70 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a process- or degradation-related impurity, Bilastine Impurity 40 (CAS 2199440-16-7, C12H15ClO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Bilastine Impurity 40 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H15ClO2 |
| Molecular Weight | 226.70 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | Cl-containing |
Related Bilastine Standards
- Bilastine impurity 90 (CAS CATO-C4X-225390)
- Bilastine impurity 92 (CAS CATO-C4X-225392)
- Bilastine impurity 85 (CAS CATO-C4X-225385)
- Bilastine impurity 80 (CAS 1789305-52-7)
- Bilastine Impurity 73 (CAS 874895-87-1)
- Bilastine Impurity 25 (CAS 137076-22-3)
- Bilastine impurity 79 (CAS 2199440-15-6)
- Bilastine Impurity 11 (CAS 1181267-33-3)
Recommended Standards
- Risperidone EP Impurity L (CAS 63234-80-0)
- Ibuprofen Impurity 51 (CAS 43153-03-3)
- 951-05-3 Phenanthrene, 9-(chloromethyl)- 9-(Chloromethyl)phenanthrene NSC 82368 (CAS 951-05-3)
- Pitolisant impurity 32 (CAS CATO-C4X-252032)
- Roflumilast Impurity 38 (CAS CATO-C4X-108438)
- Lorazepam Impurity 21 (CAS CATO-C4X-104121)
- Difelikefalin Impurity 32 Trifluoroacetic acid (CAS CATO-C4X-304132)
- Propranolol Impurity 5 (CAS 132005-35-7)
- Amoroven EP impurity L TFA Salt (CAS CATO-C4X-154222)
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