Methyl 4-chloro-8-fluoroquinoline-2-carboxylate CAS 219949-90-3
| CAS No. | 219949-90-3 |
| Molecular Formula | C11H7ClFNO2 |
| Molecular Weight | 239.63 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Methyl 4-chloro-8-fluoroquinoline-2-carboxylate (CAS 219949-90-3), molecular formula C11H7ClFNO2 and molecular weight 239.63 g/mol, is a CATO reference standard with documented purity and traceability.
Methyl 4-chloro-8-fluoroquinoline-2-carboxylate (C11H7ClFNO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures Methyl 4-chloro-8-fluoroquinoline-2-carboxylate under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C11H7ClFNO2 |
| Molecular Weight | 239.63 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2019 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Methyl Standards
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Recommended Standards
- Methyl 4-chloro-6-fluoroquinoline-2-carboxylate (CAS 301823-61-0)
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- Methyl 2-chloro-5-sulfamoylfuran-3-carboxylate (CAS 2138398-29-3)
- N1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]ethane-1,2-diamine (CAS 219478-19-0)
- methyl 1-hydroxycyclobutane-1-carboxylate (CAS 89489-58-7)
- L-Tyr-NCA (CAS 3415-08-5)
- 1-Benzyl-4-(3-bromopyridin-4-yl)piperazine (CAS 1713160-08-7)
- 3-Hydroxy-4-methoxy-5-nitrobenzoic acid (CAS 80547-65-5)
- 5-Bromo-4-(4-methoxyphenyl)-2-methyloxazole (CAS 870637-73-3)
- 1-(2-Aminoethyl)-2-(methylsulfonyl)cyclopentan-1-ol (CAS 1538052-83-3)
- 763863-61-2 {3-[(Morpholin-4-yl)methyl]phenyl}(phenyl)methanone DTXSID80607773 (CAS 763863-61-2)
- 2-(2-Chloro-6-methylpyrimidin-4-yl)ethanamine (CAS 933746-14-6)
- N-(3-(1H-imidazol-1-yl)propyl)cyclobutanamine (CAS 1251151-86-6)
- Endo-38a-Pro-Exenatide trifluoroacetate salt (CAS 1678416-95-9)
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