Methyl 4-chloro-5,8-difluoroquinoline-2-carboxylate CAS 219949-93-6
| CAS No. | 219949-93-6 |
| Molecular Formula | C11H6ClF2NO2 |
| Molecular Weight | 257.62 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Methyl 4-chloro-5,8-difluoroquinoline-2-carboxylate (CAS 219949-93-6), molecular formula C11H6ClF2NO2 and molecular weight 257.62 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Methyl 4-chloro-5,8-difluoroquinoline-2-carboxylate (C11H6ClF2NO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Methyl 4-chloro-5,8-difluoroquinoline-2-carboxylate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H6ClF2NO2 |
| Molecular Weight | 257.62 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2019 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
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Recommended Standards
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- 2,5-Difluoro-4-nitrobenzenesulfonyl chloride (CAS 1806289-42-8)
- Sodium 1-benzyl-4-(methoxycarbonyl)-2,5-dihydro-1h-pyrrol-3-olate (CAS 1788054-67-0)
- 312693-53-1 8-Quinolinamine,6-methoxy-, hydrobromide (1:1) CTK4G6738 (CAS 312693-53-1)
- 2-Chloro-1-(4-phenoxyphenyl)ethan-1-one (CAS 13075-63-3)
- 1,1,2,2-Tetrafluoro-1,2-bis(3-(trifluoromethyl)phenyl)ethane (CAS 287172-67-2)
- 3-Chloro-4-methyl-N-(pyrrolidin-2-ylmethyl)aniline hydrochloride (CAS 1177342-87-8)
- 1-Bromo-4-chlorobutane-d8 (CAS 1219803-72-1)
- 2-(5-(3-(Trifluoromethyl)phenyl)-1,3,4-oxadiazol-2-yl)acetic acid (CAS 883789-95-5)
- tert-Butyl (3-amino-1,1,1-trifluoropropan-2-yl)carbamate (CAS 1429913-34-7)
- 3-(Propylsulfinyl)-1H-1,2,4-triazol-5-amine (CAS 79742-04-4)
- (Cys2)-Neuropeptide Y-8-aminooctanoyl-(D-Cys27)-Neuropeptide Y (25-32) (H-3298.0500) (CAS 128806-04-2)
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