4-(Methylthio)-7-(trifluoromethyl)quinoline CAS 220072-35-5
| CAS No. | 220072-35-5 |
| Molecular Formula | C11H8F3NS |
| Molecular Weight | 243.25 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies 4-(Methylthio)-7-(trifluoromethyl)quinoline (CAS 220072-35-5), a certified reference material (molecular formula C11H8F3NS, MW 243.25 g/mol) for analytical method development and quality control.
4-(Methylthio)-7-(trifluoromethyl)quinoline (C11H8F3NS) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H8F3NS |
| Molecular Weight | 243.25 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2019 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Methylthio Standards
- 2-(Methylthio)-5-(5-nitrofuran-2-yl)-1,3,4-thiadiazole (CAS 3237-63-6)
- 5-(Methylthio)-3-(trifluoromethyl)isothiazole-4-carboxylic acid (CAS 157984-53-7)
- (S)-4-(Methylthio)-2-((phosphonomethyl)amino)butanoic acid (CAS 109739-03-9)
- 4-(Methylthio)-6-oxo-2-phenyl-1,6-dihydropyrimidine-5-carbonitrile (CAS 15908-64-2)
- 3-(2-(Methylthio)pyrimidin-4-yl)benzo[d]isoxazole (CAS 918870-25-4)
- (4-Methyl-6-(methylthio)pyridin-3-yl)(phenyl)methanone (CAS 1355229-64-9)
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Recommended Standards
- 2-({[(2-fluorophenyl)carbamoyl]methyl}sulfanyl)acetic acid (CAS 412923-01-4)
- 4-(Thiophen-2-yl)-2-(trifluoromethyl)aniline (CAS 2059975-00-5)
- [(4-Fluoro-phenylcarbamoyl)-methylsulfanyl]-aceticacid (CAS 412922-14-6)
- 4-(Thiophen-2-yl)-3-(trifluoromethyl)aniline (CAS 926238-47-3)
- (1R,2R)-2-(Pyridin-2-yl)cyclopropanecarboxylic acid (CAS 1287205-75-7)
- 7-Iodo-2-methylisoindolin-1-one (CAS 1379339-74-8)
- (5,5-Dimethyl-1,3-dioxan-2-yl)methanamine (CAS 1501813-06-4)
- 1-Amino-5-phenylpentan-3-ol (CAS 375799-22-7)
- 1-(tert-Butoxycarbonyl)-3-phenylpyrrolidine-2-carboxylic acid (CAS 143979-44-6)
- N-(3,5-Dimethoxyphenyl)-1,3,5-triazine-2,4-diamine (CAS 685113-65-9)
- 2-((6-Chloropyrazin-2-yl)(ethyl)amino)ethan-1-ol (CAS 1219967-25-5)
- 4-Bromopyridine-2-carbonyl chloride hydrochloride (CAS 1706438-51-8)
- Ethyl 3-amino-2-phenylpropanoate (CAS 29754-00-5)
- Insulin Degludec Impurity 28 (CAS CATO-C4X-215728)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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