2,5-Bis(trifluoromethyl)-1H-pyrrole CAS 220072-95-7
| CAS No. | 220072-95-7 |
| Molecular Formula | C6H3F6N |
| Molecular Weight | 203.09 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 2,5-Bis(trifluoromethyl)-1H-pyrrole (C6H3F6N) is characterized by a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
2,5-Bis(trifluoromethyl)-1H-pyrrole (CAS 220072-95-7), molecular formula C6H3F6N and molecular weight 203.09 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2,5-Bis(trifluoromethyl)-1H-pyrrole meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H3F6N |
| Molecular Weight | 203.09 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 2019 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Bis Standards
- 8-(trifluoromethyl)-9H-purin-2-amine (CAS 10179-89-2)
- 7-(Trifluoromethyl)imidazo[1,2-a]pyrimidin-5(8H)-one (CAS 1018125-95-5)
- 8-(Trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one (CAS 1020039-20-6)
- 2-(Trifluoromethyl)pyrazolo[1,5-a]pyrimidin-5(4H)-one (CAS 1239462-26-0)
- 4-(Trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-3-ol (CAS 1242267-84-0)
- 3-(Trifluoromethyl)benzo[d]isoxazol-5-ol (CAS 1260839-35-7)
- 6-(Trifluoromethyl)pyridine-2,4-dicarbaldehyde (CAS 1393550-38-3)
- 4-(Trifluoromethyl)pyridine-2,6-dicarbaldehyde (CAS 1393550-50-9)
Recommended Standards
- 2,3-Dichloro-1-benzothiophene (CAS 5323-97-7)
- 3,6-Dichlorobenzo[b]thiophene (CAS 21211-21-2)
- (4-Nitrophenyl)phosphonic acid (CAS 2175-86-2)
- 4,7-Dichlorobenzo[b]thiophene (CAS 318463-07-9)
- Ethyl isothiocyanato(phenyl)acetate (CAS 201139-10-8)
- trans-4-(4-methylpiperazin-1-yl)cyclohexan-1-amine (CAS 883195-08-2)
- Hispolon (CAS 173933-40-9)
- N-(2-Methoxyphenyl)-4-pentylcyclohexane-1-carboxamide (CAS 866137-28-2)
- 3-Amino-N-(3-chloro-4-fluorophenyl)benzamide (CAS 1018277-98-9)
- 3-Amino-4-(isopropylamino)benzonitrile (CAS 355022-20-7)
- N-(2-Cyano-3-methylbutan-2-yl)-2-(naphthalen-2-ylthio)acetamide (CAS 851472-52-1)
- 4-(2-(Trifluoromethyl)phenyl)-1,2,3,6-tetrahydropyridine hydrochloride (CAS 208989-34-8)
- Methyl 2-[(E)-2-(dimethylamino)vinyl]-6-(3,5-dimethyl-4H-1,2,4-triazol-4-yl)-5-oxo-5,6-dihydro-1,6-naphthyridine-3-carboxylate (CAS 1374510-86-7)
- [Formaldehyde Schiff-base]-Semaglutide Impurity 136 X TFA Salt (CAS CATO-C4X-2226136)
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