Ibuprofen Impurity CAS 220089-22-5
| CAS No. | 220089-22-5 |
| Molecular Formula | C12H14O3 |
| Molecular Weight | 206.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 206.24 g/mol gives Ibuprofen Impurity distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Ibuprofen Impurity (CAS 220089-22-5) is a certified pharmaceutical impurity reference standard with the molecular formula C12H14O3 and a molecular weight of 206.24 g/mol.
The molecular framework of Ibuprofen Impurity (C12H14O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H14O3 |
| Molecular Weight | 206.24 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2019 |
Related Ibuprofen Standards
- Ibuprofen Impurity 25 (CAS 43153-04-4)
- (S)-Ibuprofen EP Impurity B (CAS 404354-76-3)
- Ibuprofen (CAS 15687-27-1)
- Ibuprofen EP Impurity A (CAS 66622-47-7)
- Ibuprofen Impurity 145 (CAS 69363-33-3)
- Ibuprofen EP Impurity A (CAS CATO-C4X-1082147)
- Ibuprofen EP Impurity O (CAS 64451-76-9)
- Ibuprofen Impurity 151 (CAS CATO-C4X-1082151)
Recommended Standards
- Vortioxetine Impurity 90 (CAS 50606-33-2)
- Hydroxypiperidine-2-carboxylic Acid (CAS 56879-47-1)
- Posaconazole Impurity 119 (CAS 2243786-03-8)
- 1-(4-carboxyphenyl) piperazine 4-(1-piperazinyl)-benzoic acid 4-(1-piperazinyl)benzoic acid 4-(Piperazin-1-yl)-benzoic acid 4-(piperazin-1-yl)benzoic acid 4-piperazin-1-yl-benzoic acid 4-piperazin-1-ylbenzoic acid 85474-75-5 (CAS 85474-75-5)
- Gadobutrol Impurity 153 (CAS CATO-C4X-2120153)
- yptophan Impurity 29 (CAS 129784-88-9)
- Tucatinib Impurity 46 (CAS CATO-C4X-260546)
- 1-(6-Chloropyridazin-3-yl)piperidin-3-ol (CAS 939986-92-2)
- Indacaterol Impurity 70 (CAS CATO-C4X-150070)
- 6-(Trifluoromethyl)-1H-pyrrolo[3,2-b]pyridin-3-amine (CAS 1190311-51-3)
- Ethyl 5-iodopentanoate (CAS 41302-32-3)
- 6,6-Dimethyldihydro-2H-pyran-2,4(3H)-dione (CAS 84465-82-7)
- 4-Bromoisoquinolin-8-amine (CAS 351458-46-3)
- Fibronectin Adhesion-Promoting Peptide (CAS 125720-21-0)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com