3-Fluoro-3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione CAS 220460-63-9
| CAS No. | 220460-63-9 |
| Molecular Formula | C13H11FN2O3 |
| Molecular Weight | 262.24 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-Fluoro-3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione.
3-Fluoro-3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione (CAS 220460-63-9) is a high-purity analytical reference standard with the molecular formula C13H11FN2O3 and a molecular weight of 262.24 g/mol.
The molecular framework of 3-Fluoro-3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione (C13H11FN2O3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 3-Fluoro-3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H11FN2O3 |
| Molecular Weight | 262.24 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2019 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Fluoro Standards
- Ethyl 2-fluoro-4-(2-hydroxypyrimidin-5-yl)benzoate (CAS 1111104-20-1)
- 2-(8-Fluoro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)-2-oxoacetic acid (CAS 1144466-00-1)
- 2-(5-Fluoro-6-oxocyclohexa-2,4-dien-1-yl)ethyl pyrimidine-4-carboxylate (CAS 143329-00-4)
- 3-(4-Fluoro-1-oxo-2-isoindolinyl)piperidine-2,6-dione (CAS 1884230-69-6)
- (3S)-3-(5-fluoro-1-oxo-isoindolin-2-yl)piperidine-2,6-dione (CAS 1884230-70-9)
- (3S)-3-(6-fluoro-1-oxo-isoindolin-2-yl)piperidine-2,6-dione (CAS 1884230-71-0)
- 2-{[(4-fluoro-3-nitrophenyl)amino]methyl}phenol (CAS 329779-30-8)
- 3-(5-fluoro-1-oxo-isoindolin-2-yl)piperidine-2,6-dione (CAS 2468780-76-7)
Recommended Standards
- 3-Acetyl-N-(4-fluorophenyl)-5-methylisoxazole-4-carboxamide (CAS 338954-23-7)
- 4-Acetamido-N-(4-fluorophenyl)-1H-pyrazole-3-carboxamide (CAS 844440-86-4)
- 3-(7-Fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione (CAS 2287267-33-6)
- 4-Fluoro-2-(2-oxopiperidin-3-yl)isoindoline-1,3-dione (CAS 2324143-09-9)
- Benzyl 3-(((2-aminoethyl)thio)methyl)pyrrolidine-1-carboxylate (CAS 1353953-73-7)
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