利伐沙班杂质53 CAS 2206360-84-9
| CAS No. | 2206360-84-9 |
| Molecular Formula | C16H22Cl2N2O4 |
| Molecular Weight | 377.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 377.26 g/mol gives 利伐沙班杂质53 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, 利伐沙班杂质53 (CAS 2206360-84-9, C16H22Cl2N2O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of 利伐沙班杂质53 (C16H22Cl2N2O4) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), 利伐沙班杂质53 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H22Cl2N2O4 |
| Molecular Weight | 377.26 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Recommended Standards
- tert-Butyl 6-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate (CAS 2204252-89-9)
- 4-Bromo-2-(2-(4-(tert-butyl)phenoxy)ethoxy)benzaldehyde (CAS 1432437-10-9)
- tert-butyl 4-(3-iodo-1-bicyclo[1.1.1]pentanyl)piperidine-1-carboxylate (CAS 2020069-99-0)
- (5-Bromo-2-methoxyphenyl)methyl 4-tert-butylbenzoate (CAS 331460-30-1)
- Dotinurad Impurity 47 (CAS CATO-C4X-249447)
- Levofloxacin Impurity 47 (CAS 110548-06-6)
- Doxepin Impurity 2 (CAS 131523-93-8)
- 2-[2-(Propan-2-ylsulfanyl)ethyl]piperidine hydrochloride (CAS 1820718-02-2)
- rel-tert-Butyl (3R,4S)-3-hydroxy-4-(trifluoromethyl)pyrrolidine-1-carboxylate (CAS 2368911-19-5)
- 7-Hydroxybenzofuran-2-carboxylic acid (CAS 4790-80-1)
- Diethyl[(5-fluoro-2-nitrophenyl)methyl]amine hydrochloride (CAS 1881332-24-6)
- FBA 393 (CAS 1533-45-5)
- Mivacurium Chloride Impurity 16 (CAS CATO-C4X-137516)
- 1-His-N-a-ethylidene Semaglutide (CAS CATO-C4X-2226252)
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